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Titolo:
Regulation of ocular inflammation - what experimental and human studies have taught us
Autore:
de Smet, MD; Chan, CC;
Indirizzi:
Univ Amsterdam, Dept Ophthalmol, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands Ophthalmol, Amsterdam, Netherlands NEI, Immunopathol Lab, Bethesda, MD 20892 USA NEI Bethesda MD USA 20892NEI, Immunopathol Lab, Bethesda, MD 20892 USA
Titolo Testata:
PROGRESS IN RETINAL AND EYE RESEARCH
fascicolo: 6, volume: 20, anno: 2001,
pagine: 761 - 797
SICI:
1350-9462(200111)20:6<761:ROOI-W>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; ENDOTOXIN-INDUCED UVEITIS; RETINOID-BINDING-PROTEIN; KOYANAGI-HARADA-DISEASE; MYELIN BASIC-PROTEIN; TUMOR-NECROSIS-FACTOR; HEAT-SHOCK-PROTEIN; CELLULAR IMMUNE-RESPONSES; THYROID-ASSOCIATED OPHTHALMOPATHY; RESIDENT-TISSUE MACROPHAGES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
374
Recensione:
Indirizzi per estratti:
Indirizzo: de Smet, MD Univ Amsterdam, Dept Ophthalmol, Kruislaan 403, Amsterdam, Netherlands Univ Amsterdam Kruislaan 403 Amsterdam Netherlands therlands
Citazione:
M.D. de Smet e C.C. Chan, "Regulation of ocular inflammation - what experimental and human studies have taught us", PROG RET EY, 20(6), 2001, pp. 761-797

Abstract

Study of models of ocular autoimmunity and of autoimmune uveitis in humanshas lead to a shift in the perceived nature of immune privilege from one based on anatomical isolation oft lie eye to a more dynamic, active process of immune tolerance. Using a variety of available models, the basis for this dynamic process of immune regulation is reviewed. The protective role of humoral immunity, the co-stimulatory function of B cells in EAU as well as the influence of cytokines within the inflammatory cascade are outlined. Modulation of the immune response and in particular the possible role of macrophages is explored. Within the current paradyme, a major effector cell is the CD4+ lymphocyte. Its maturation into a Th1 or Th2 phenotype process appears dependent on a number of exogenous factors, which while genetically determined can be manipulated prior to disease onset, Activation of CD4+ cells is dependent on presentation of immunoreactive peptide fragments, These fragments are well characterized in the Lewis rat for S-Ag and interphotoreceptor retinoid binding protein (IRBP). Mapping of the immunoreactivity to S-Ag has been recently completed in uveitis patients. An overlap with certain determinants identified in experimental models has been observed, in at least 2 disease entities. However, the response profile is not Fixed in timeand is subject to determinant spread. Future studies will be aimed at identifying with more detail immunologic triggers of inflammation in patients. and at better defining the interplay between effector and regulatory pathways both in the eye and in the systemic circulation. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:49:09