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Titolo:
Recent advances in our understanding of rhodopsin and phototransduction
Autore:
Pepe, IM;
Indirizzi:
Univ Genoa, Fac Med, Inst Biophys, I-16132 Genoa, Italy Univ Genoa GenoaItaly I-16132 c Med, Inst Biophys, I-16132 Genoa, Italy
Titolo Testata:
PROGRESS IN RETINAL AND EYE RESEARCH
fascicolo: 6, volume: 20, anno: 2001,
pagine: 733 - 759
SICI:
1350-9462(200111)20:6<733:RAIOUO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROD OUTER SEGMENTS; LIMULUS VENTRAL PHOTORECEPTORS; RESONANCE RAMAN-SPECTROSCOPY; SCHIFF-BASE COUNTERION; PRIMARY PHOTOCHEMICAL EVENTS; VERTEBRATE VISUAL PIGMENTS; STATIONARY NIGHT BLINDNESS; GUANYLATE-CYCLASE ACTIVITY; NUCLEOTIDE-GATED CHANNELS; CGMP-ACTIVATED CHANNELS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
275
Recensione:
Indirizzi per estratti:
Indirizzo: Pepe, IM Univ Genoa, Fac Med, Inst Biophys, Corso Europa 30,Salita Super Noce 35, I-16132 Genoa, Italy Univ Genoa Corso Europa 30,Salita Super Noce 35 Genoa Italy I-16132
Citazione:
I.M. Pepe, "Recent advances in our understanding of rhodopsin and phototransduction", PROG RET EY, 20(6), 2001, pp. 733-759

Abstract

The present models of phototransduction for vertebrates and invertebrates have been reviewed and the relative literature updated. The emerging picture for vertebrate photo transduction is a result of a better knowledge of its general outlines, although some important details such as the role of calcium ions are still lacking. The molecular events involved in the rising phase of the electrical response have basically been understood, whilst thoseinvolved in response inactivation and recovery remain to be elucidated. Inan overall strategy, the phototransduction in invertebrates shares a greatdeal of similarity with that in vertebrates but differs in the underlying molecular events. However, a complete picture of phototransduction in invertebrate photoreceptors has not yet emerged. The available data on the structure of the visual pigment rhodopsin revealfurther details on the present model of the retinal-binding pocket of the protein and consequently of the "red shift" of the absorbance of retinal. The problem of the energy supplied during photoreception, in particular, the availability of ATP in the rod outer segment and the presence in the disk membranes of a Ca-ATPase are discussed, Finally, recent progress in understanding the molecular mechanisms of inherited retinal diseases and relative gene identification are summarized. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:36:10