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Titolo:
Renal tolerance to selective inhibitors of cyclooxygenase type 2
Autore:
Deray, G;
Indirizzi:
Grp Hosp Pitie Salpetriere, Serv Nephrol, F-75013 Paris, France Grp Hosp Pitie Salpetriere Paris France F-75013 l, F-75013 Paris, France
Titolo Testata:
PRESSE MEDICALE
fascicolo: 30, volume: 30, anno: 2001,
pagine: 1507 - 1512
SICI:
0755-4982(20011020)30:30<1507:RTTSIO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
FRE
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID-ARTHRITIS; BLOOD-PRESSURE; GASTROINTESTINAL TOXICITY; RENIN CONTENT; INDOMETHACIN; CELECOXIB; SODIUM; OSTEOARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Deray, G Grp Hosp Pitie Salpetriere, Serv Nephrol, 83 Bd Hop, F-75013 Paris, France Grp Hosp Pitie Salpetriere 83 Bd Hop Paris France F-75013 France
Citazione:
G. Deray, "Renal tolerance to selective inhibitors of cyclooxygenase type 2", PRESSE MED, 30(30), 2001, pp. 1507-1512

Abstract

Antiinflammatory drugs Non-steroidal antiinflammatory drugs (NSAID) constitute one of the most widely prescribed drug classes. Selective inhibitors of cyclooxygenase type 2 (Cox-2) can have antiinflammatory and antialgesic activities without affecting prostaglandin synthesis at sites where classical NSAID have known toxicity. This fact has led to the development of celebrex and rofecoxib, the leading selective inhibitors of Cox-2. We review herethe renal effects of steroidal antiinflammatory drugs. Renal effects of NSAID The renal effects of NSAlD are, in decreasing order: electrolyte imbalance (hyperkaliemia, edema, hypertension), acute renal failure, nephrotic syndrome associated with interstitial nephropathy, papillary necrosis. Electrolyte disorders and acute renal failure are observed more frequently in patients with risk factors. Intrarenal localization of cyclooxygenase Cox-1 is present in endothelial and smooth muscle cells of pre- and postglomerular vessels as well as in the cortex, the medullary tubes and in interstitial cells. Cox-2 expression has been identified in the interstitium, medullary tubes and intercalate cells, and in the deep medulla. The regulatory role of Cox-2 on renin production has been demonstrated in the macula densa. Renal effects of Cox-2 inhibitors Several studies have demonstrated that Cox-2 inhibitors inhibit prostaglandin synthesis much like conventional NSAID. The long-term effects of selective inhibitors of Cox-2 on blood pressure, edema, kaliemia and renal function have also been described. All these studies point to the strictly identical renal effects of these new drugs and conventional NSAID.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:54:27