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Titolo:
Biologically effective uniform dose (D) for specification, report and comparison of dose response relations and treatment plans
Autore:
Mavroidis, P; Lind, BK; Brahme, A;
Indirizzi:
Karolinska Inst, Dept Med Radiat Phys, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Phys, S-17176 Stockholm, Sweden Stockholm Univ, S-17176 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-17176 Univ, S-17176 Stockholm, Sweden
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 10, volume: 46, anno: 2001,
pagine: 2607 - 2630
SICI:
0031-9155(200110)46:10<2607:BEUD(F>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFORMAL RADIATION-THERAPY; TUMOR-CONTROL; NORMAL TISSUE; OPTIMIZATION; MODEL; PROBABILITY; VOLUME; RADIOTHERAPY; IRRADIATION; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mavroidis, P Karolinska Inst, Dept Med Radiat Phys, POB 260, S-17176 Stockholm, Sweden Karolinska Inst POB 260 Stockholm Sweden S-17176 olm, Sweden
Citazione:
P. Mavroidis et al., "Biologically effective uniform dose (D) for specification, report and comparison of dose response relations and treatment plans", PHYS MED BI, 46(10), 2001, pp. 2607-2630

Abstract

Developments in radiation therapy planning have improved the information about the three-dimensional dose distribution in the patient. Isodose graphs, dose volume histograms and most recently radiobiological models can be used to evaluate the dose distribution delivered to the irradiated organs andvolumes of interest. The concept of a biologically effective uniform dose (D)double over bar assumes that any two dose distributions are equivalent if they cause the same probability for tumour control or normal tissue complication. In the present paper the (D)double over bar concept both for tumours and normal tissues is presented, making use of the fact that probabilities averaged over both dose distribution and organ radiosensitivity are morerelevant to the clinical outcome than the expected number of surviving clonogens or functional subunits. (D)double over bar can be calculated in complex target volumes or organs at risk either from the 3D dose matrix or fromthe corresponding dose volume histograms of the dose plan. The value of the (D)double over bar concept is demonstrated by applying it to two treatment plans of a cervix cancer. Comparison is made of the (D)double over bar concept with the effective dose (D-eff) and equivalent uniform dose (EUD) that have been suggested in the past. The value of the concept for complex targets and fractionation schedules is also pointed out.

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Documento generato il 28/11/20 alle ore 18:15:20