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Titolo:
NO EVIDENCE FOR A SCHIZOPHRENIA SUSCEPTIBILITY GENE IN THE VICINITY OF IL2RB ON CHROMOSOME-22
Autore:
PARSIAN A; SUAREZ BK; ISENBERG K; HAMPE CL; FISHER L; CHAKRAVERTY S; MESZAROS K; LENZINGER E; WILLINGER U; FUCHS K; ASCHAUER HN; CLONINGER CR;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 UNIV VIENNA,DEPT GEN PSYCHIAT A-1010 VIENNA AUSTRIA
Titolo Testata:
American journal of medical genetics
fascicolo: 4, volume: 74, anno: 1997,
pagine: 361 - 364
SICI:
0148-7299(1997)74:4<361:NEFASS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL LINKAGE; SEGREGATION ANALYSIS; FOLLOW-UP; LOCUS; 22Q12-Q13.1; DISORDERS; MARKERS;
Keywords:
SCHIZOPHRENIA; CHROMOSOME 22; LINKAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Parsian et al., "NO EVIDENCE FOR A SCHIZOPHRENIA SUSCEPTIBILITY GENE IN THE VICINITY OF IL2RB ON CHROMOSOME-22", American journal of medical genetics, 74(4), 1997, pp. 361-364

Abstract

Pulver et al. [1994a] reported modest linkage evidence for a dominantly (D) inherited ''schizophrenia gene'' in the vicinity of IL2RB on chromosome 22q12, and Goon et al, [1994] adduced moderate evidence undera recessive (R) model, We report here a replication study to test thehypothesis that one of these two models (or a third, intermediate (I)model) adequately describes the cosegregation of schizophrenia and chromosome 22q12 markers in an independent sample of 23 multiplex families, Altogether nine transmission models were evaluated, The models differed depending on whether the 15 family members with a diagnosis of schizophrenia spectrum disorders were considered unaffected (a ''narrow'' (N) definition), affected (a ''wide'' (W) definition), or declared ''unknown'' (U), The entire region between D225268 and D22S307 is excluded (i.e., lod <-2) for models RN, RW, RU, and IW, Lod scores for theremaining models are uniformly negative; albeit, equivocal with respect to the dominant hypothesis over a small region between D22S268 and IL2RB, Nonparametric analysis under both diagnostic criteria also failed to yield any evidence for a susceptibility locus in this region of chromosome 22. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 01/10/20 alle ore 03:57:13