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Titolo:
Inactivation of pulmonary surfactant and the treatment of acute lung injuries
Autore:
Taeusch, HW; Keough, KMW;
Indirizzi:
Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Mem Univ Newfoundland, St Johns, NF, Canada Mem Univ Newfoundland St Johns NF Canada foundland, St Johns, NF, Canada
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 6, volume: 20, anno: 2001,
pagine: 519 - 536
SICI:
1522-7952(200111/12)20:6<519:IOPSAT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; MECONIUM ASPIRATION SYNDROME; WATER-SOLUBLE POLYMERS; ACID ASPIRATION; PLASMA-PROTEINS; INTRATRACHEAL ENDOTOXIN; AEROSOLIZED SURFACTANT; BOVINE SURFACTANT; BLOOD PROTEINS; ANIMAL-MODEL;
Keywords:
acute lung injury; inactivation; nonionic polymers; polyethylene glycol; pulmonary surfactant; surfactant proteins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Taeusch, HW SFGH, Dept Pediat, 1001 Potrero Ave, San Francisco, CA 94114 USA SFGH 1001 Potrero Ave San Francisco CA USA 94114 CA 94114 USA
Citazione:
H.W. Taeusch e K.M.W. Keough, "Inactivation of pulmonary surfactant and the treatment of acute lung injuries", PEDIAT PATH, 20(6), 2001, pp. 519-536

Abstract

Inactivation of pulmonary surfactant may be important in acute lung injuryand acute respiratory distress syndrome. Treatment of surfactant dysfunction by instilling exogenous surfactants may improve gas exchange and pulmonary mechanics. Surfactants used for treatment vary in their attributes and effects, so when various surfactants are considered for therapy, resistance to inactivation is an important consideration. Animal models of acute lung injury exist in which the relative merits of surfactants call be compared. We hypothesize that the surfactants most resistant to inactivation in vitrowill be the ones that are most effective in treatment of animal models of acute lung injury. Surfactants with higher concentrations of surfactant proteins (specifically A, B, and C) are more resistant to inactivation. Nonionic polymers mimic surfactant proteins in Preventing surfactant inactivationunder some conditions. Adding nonionic polymers to surfactant containing minimal amounts of SP-B and SP-C markedly improves lung function of animals with lung injury. Making surfactants more "inactivotion-proof' may improve surfactant therapy of acute lung injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:45:13