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Titolo:
Evidence for abnormal pain processing in fibromyalgia syndrome
Autore:
Staud, R; Domingo, M;
Indirizzi:
Univ Florida, Dept Rheumatol & Clin Immunol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Immunol, Gainesville, FL 32610 USA
Titolo Testata:
PAIN MEDICINE
fascicolo: 3, volume: 2, anno: 2001,
pagine: 208 - 215
SICI:
1526-2375(200109)2:3<208:EFAPPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; POSTTRAUMATIC-STRESS-DISORDER; POSITRON EMISSION TOMOGRAPHY; HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC-FATIGUE-SYNDROME; CEREBRAL BLOOD-FLOW; GROWTH-HORMONE; GENERAL-POPULATION; CAUDATE-NUCLEUS; NMDA RECEPTOR;
Keywords:
FMS; pain; sensitization; therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Staud, R Univ Florida, Dept Rheumatol & Clin Immunol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
R. Staud e M. Domingo, "Evidence for abnormal pain processing in fibromyalgia syndrome", PAIN MED, 2(3), 2001, pp. 208-215

Abstract

Objective. To review die pathophysiology of fibromyalgia syndrome. Design. Review of the literature available on Medline (1965-2001). Results. Fibromyalgia syndrome is a chronic pain syndrome that predominantly afflicts, women. It is characterized by widespread pain, insomnia, fatigue, and the presence of multiple tender points. Despite intensifying research, the etiology of fibromyalgia has remained unclear. Importantly, neitherinfections, trauma, nor psychiatric abnormalities consistently precede theonset of pain in patients with this syndrome. There is, however, mounting evidence for central pain processing abnormalities in almost all fibromyalgia patients. These anomalies include hyperalgesia, allodynia, abnormal temporal summation of second pain, neuroendocrine abnormalities, and abnormal activation of pain-related brain regions. Conclusions. Multiple abnormal findings in fibromyalgia patients strongly indicate a neuropathic. pain syndrome, reminiscent of complex regional painsyndrome or postherpetic neuralgia. In addition, fibromyalgia syndrome seems to share similar characteristics with these neuropathic pain syndromes,.including ineffective response to many analgesics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:07:47