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Titolo:
Biochemical composition of equine carpal articular cartilage is influencedby short-term exercise in a site-specific manner
Autore:
Murray, RC; Birch, HL; Lakhani, K; Goodship, AE;
Indirizzi:
Anim Hlth Trust, Ctr Equine Studies, Newmarket CB8 7UU, Suffolk, England Anim Hlth Trust Newmarket Suffolk England CB8 7UU 8 7UU, Suffolk, England Univ London Royal Vet Coll, London NW1 0TU, England Univ London Royal Vet Coll London England NW1 0TU ondon NW1 0TU, England
Titolo Testata:
OSTEOARTHRITIS AND CARTILAGE
fascicolo: 7, volume: 9, anno: 2001,
pagine: 625 - 632
SICI:
1063-4584(200110)9:7<625:BCOECA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRINSIC MECHANICAL-PROPERTIES; COLLAGEN NETWORK; CHIP FRACTURES; KNEE-JOINT; OSTEOARTHRITIS; HORSES; ZONE; AGE; GLYCOSAMINOGLYCANS; METABOLISM;
Keywords:
equine; physical training; cartilage; extracellular matrix;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Murray, RC Anim Hlth Trust, Ctr Equine Studies, Lanwades Pk, Newmarket CB87UU, Suffolk, England Anim Hlth Trust Lanwades Pk Newmarket Suffolk England CB8 7UU d
Citazione:
R.C. Murray et al., "Biochemical composition of equine carpal articular cartilage is influencedby short-term exercise in a site-specific manner", OSTEO CART, 9(7), 2001, pp. 625-632

Abstract

It was hypothesized that cartilage macro-molecular characteristics are influenced by exercise intensity and by location within a jointObjective: To determine the macromolecular characteristics of carpal articular cartilage at common and uncommon sites of pathology in horses undergoing high or low intensity exercise, and to compare this composition between exercise groups. Design: Twelve horses (19.3 +/- 0.9 years) were assigned to exercise groups. Each group underwent 19 weeks high-intensity treadmill training (N=6) orlow-intensity exercise (N=6). Dorsal and palmar test sites were identifiedon radial, intermediate and third carpal articular surfaces after euthanasia. Cartilage was collected from each site, freeze-dried and assessed for water content. Hydroxyproline, glycosaminoglycan and DNA analyses were performed on cartilage from each test site. Adjacent cartilage underwent histological preparation and assessment for chondrocyte numerical density at each site and proteoglycan distribution through the depth of cartilage. Results: Dorsal cartilage had a higher collagen content, DNA content, and chondrocyte numerical density, but lower glycosaminoglycan content than palmar cartilage. Cartilage from horses undergoing high-intensity training hada significantly higher glycosaminoglycan content than cartilage from horses undergoing low-intensity exercise, with maximal difference being observedin cartilage from dorsal radial and dorsal intermediate carpal articular surfaces. Overall no effect of exercise on collagen was observed, but at sites predisposed to clinical lesions cartilage from horses undergoing high-intensity training contained significantly less collagen than from horses undergoing low-intensity exercise. Distribution of proteoglycan was non-uniform in 52% of the sections examined, with superficial loss of toluidine blue staining primarily at dorsal sites and in the high-intensity exercise group. Conclusions: These results indicate that topographical and exercise related differences exist in carpal cartilage composition, and that the effect ofexercise on overall composition and distribution within the cartilage was maximal at sites predisposed to clinical lesions. These findings could indicate that the combined effect of exercise and local load variations within a joint may lead to a risk of exceeding the physiologic threshold at high load sites that are predisposed to clinical injury. (C) 2001 OsteoArthritis Research Society International.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:16:12