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Titolo:
Compatibility of the thioamide functional group with beta-sheet secondary structure: Incorporation of a thioamide linkage into a beta-hairpin peptide
Autore:
Miwa, JH; Patel, AK; Vivatrat, N; Popek, SM; Meyer, AM;
Indirizzi:
Wellesley Coll, Dept Chem, Wellesley, MA 02481 USA Wellesley Coll Wellesley MA USA 02481 Dept Chem, Wellesley, MA 02481 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 21, volume: 3, anno: 2001,
pagine: 3373 - 3375
SICI:
1523-7060(20011018)3:21<3373:COTTFG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANALOGS; DESIGN; CONFORMATIONS; DERIVATIVES; THIOPEPTIDE; NUCLEATION; SEQUENCE; STRATEGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Miwa, JH Wellesley Coll, Dept Chem, Wellesley, MA 02481 USA Wellesley Coll Wellesley MA USA 02481 m, Wellesley, MA 02481 USA
Citazione:
J.H. Miwa et al., "Compatibility of the thioamide functional group with beta-sheet secondary structure: Incorporation of a thioamide linkage into a beta-hairpin peptide", ORG LETT, 3(21), 2001, pp. 3373-3375

Abstract

[GRAPHICS]We report the incorporation of a thioamide linkage between the i + 2 and i+ 3 residues of the type II' beta -turn of a peptide known to fold into a beta -hairpin conformation. Two-dimensional NMR spectroscopy and circular dichroism spectroscopy indicate that the thioxo peptide adopts a hairpin conformation similar to that of the oxo peptide and that the hairpin conformation persists at elevated temperatures. The results show that a thioamide linkage is compatible with beta -sheet secondary structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:23:05