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Titolo:
Nutritional aspects of nitric oxide: Human health implications and therapeutic opportunities
Autore:
Janero, DR;
Indirizzi:
NitroMed Inc, Bedford, MA 01730 USA NitroMed Inc Bedford MA USA 01730NitroMed Inc, Bedford, MA 01730 USA
Titolo Testata:
NUTRITION
fascicolo: 10, volume: 17, anno: 2001,
pagine: 896 - 903
SICI:
0899-9007(200110)17:10<896:NAONOH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; LIPID PEROXYL RADICALS; PROTEIN-KINASE-C; VITAMIN-E; ALPHA-TOCOPHEROL; FOOD-INTAKE; SYNTHASE ACTIVITY; OXIDATIVE STRESS;
Keywords:
nitric oxide synthase; gastrointestinal homeostasis; inflammation; blood vessels; nutrients; vitamins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Janero, DR NitroMed Inc, 12 Oak Pk Dr, Bedford, MA 01730 USA NitroMed Inc 12 Oak Pk Dr Bedford MA USA 01730 rd, MA 01730 USA
Citazione:
D.R. Janero, "Nutritional aspects of nitric oxide: Human health implications and therapeutic opportunities", NUTRITION, 17(10), 2001, pp. 896-903

Abstract

Nitric oxide (NO), the most potent natural vasorelaxant known, has close historical ties to cardiovascular physiology, despite NO's rich physiologic chemistry as an ubiquitous, signal-transducing radical. Aspects of NO biology critical to gastrointestinal health and, consequently, nutritional status are increasingly being recognized. Attempts are underway to exploit the gastrointestinal actions of NO for therapeutic gain. Cross-talk between NO and micronutrients within and outside the gastrointestinal system affects the establishment or progression of several diseases with pressing medical needs. These concepts imply that NO biology can influence nutrition and be nutritionally modulated to affect mammalian (patho)physiology. At least four nutritional facets of NO biology are at the forefront of contemporary biomedical research: 1) NO as modulator of feeding behavior and mediator of gastrointestinal homeostasis; 2) NO supplementation as a therapeutic modality for preserving gastrointestinal health; 3) interactions among elemental micronutrients (e.g., zinc), NO, and inflammation as potential contributors to diarrheal disease; and 4) vitamin micronutrients vitamins E and C) as protectors of NO-dependent vascular function. Discussion of extant data on thesetopics prompts speculation that future research will broaden NO's nutritional role as an integrative signaling molecule supporting gastrointestinal and nutritional well-being. Nutrition 2001;17:896-903. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:02:54