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Titolo:
Folic acid: Are current fortification levels adequate?
Autore:
Neuhouser, ML; Beresford, SAA;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA
Titolo Testata:
NUTRITION
fascicolo: 10, volume: 17, anno: 2001,
pagine: 868 - 872
SICI:
0899-9007(200110)17:10<868:FAACFL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; TOTAL HOMOCYSTEINE CONCENTRATIONS; METHYLENETETRAHYDROFOLATE REDUCTASE; COBALAMIN DEFICIENCY; FOOD FORTIFICATION; DIETARY-FOLATE; SERUM FOLATE; VITAMIN-B-12; WOMEN; RISK;
Keywords:
folic acid; neural tube defects; biomarkers; surveillance; fortification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Beresford, SAA Univ Washington, Dept Epidemiol, Box 357236, Seattle, WA 98195 USA Univ Washington Box 357236 Seattle WA USA 98195 A 98195 USA
Citazione:
M.L. Neuhouser e S.A.A. Beresford, "Folic acid: Are current fortification levels adequate?", NUTRITION, 17(10), 2001, pp. 868-872

Abstract

OBJECTIVE: Beginning on January 1, 1998, all cereal and grain products in the United States were fortified with folic acid to reduce the occurrence of the very common congenital malformations known as neural-tube defects. Three years have passed since the fortification program began, and it is timeto evaluate whether the current fortification levels have met their intended objective,METHODS: We offer an overview of folate and its potential role in the etiology of neural-tube defects, review some of the highlights of the deliberations that led to the decision by the Food and Drug Administration to fortify the food supply, and offer a perspective on how to measure whether current fortification levels are adequate. RESULTS: There is no national system in the United States that monitors neural-tube and other birth defects over time, and no postmarketing surveillance was mandated to monitor the safety of the fortification program. Therefore, we must evaluate the program in other ways. Blood biomarkers of folatestatus such as the levels of folate in red blood cells and homocysteine inplasma provided the best evidence of the effectiveness of the folic-acid-fortification program because of their relatively high sensitivities in relation to their specificities as markers of folate status. In addition, thesebiomarkers might provide information about the risks of other diseases related to folate status such as vascular disease. CONCLUSION: Federal agencies should coordinate efforts to gather and evaluate markers of folate status at the population level. These measures can beused to evaluate the safety and efficacy of folic-acid fortification and whether changes are warranted in fortification levels. Nutrition 2001;17:868-872. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:32:02