Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Improving influence of insulin on cognitive functions in humans
Autore:
Kern, W; Peters, A; Fruehwald-Schultes, B; Deininger, E; Born, J; Fehm, HL;
Indirizzi:
Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 al Med 1, D-23538 Lubeck, Germany Med Univ Lubeck, Dept Clin Neuroendocrinol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 docrinol, D-23538 Lubeck, Germany
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 4, volume: 74, anno: 2001,
pagine: 270 - 280
SICI:
0028-3835(200110)74:4<270:IIOIOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; RAT-BRAIN; ENDOGENOUS POTENTIALS; HIPPOCAMPAL-FORMATION; GLUCOSE-UTILIZATION; ALZHEIMERS-DISEASE; DIABETES-MELLITUS; MEMORY-SEARCH;
Keywords:
insulin; cognitive functions; auditory potentials; attention; mood; memory; clinical neuroendocrinology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Kern, W Med Univ Lubeck, Dept Internal Med 1, Ratzeburger Allee 160, D-23538 Lubeck, Germany Med Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538 many
Citazione:
W. Kern et al., "Improving influence of insulin on cognitive functions in humans", NEUROENDOCR, 74(4), 2001, pp. 270-280

Abstract

Insulin receptors have been identified in limbic brain structures, but their functional relevance is still unclear. In order to characterize some of their effects, we evaluated auditory evoked brain potentials (AEP) in a vigilance task, behavioral measures of memory (recall of words) and selective attention (Stroop test) during infusion of insulin. The hormone was infusedat two different rates (1.5 mU/kg x min, 'low insulin', and 15 mU/kg x min, 'high insulin'), inducing respectively serum levels of 543 +/- 34 and 24,029 +/- 1,595 pmol/l. This experimental design allowed to compare cognitiveparameters under two conditions presenting markedly different insulin levels, but with minimal incidence on blood glucose concentrations since these were kept constant by glucose infusion. A 'no insulin treatment' group was not included in order to avoid leaving patients infused with glucose without insulin treatment. Measures were taken during a baseline phase preceding insulin infusion and every 90 min during the 360 min of insulin infusion. Compared with 'low insulin', 'high insulin' induced a slow negative potential shift in the AEP over the frontal cortex (average amplitude, high insulin: 0.27 +/- 0.48 muV; low insulin: 1.87 +/- 0.48 muV, p < 0.005), which was paralleled by enhanced memory performance (words recalled, high insulin: 22.04 +/- 0.93; low insulin: 19.29 +/- 0.92, p < 0.05). Also, during 'high insulin' subjects displayed enhanced performance on the Stroop test (p < 0.05) and expressed less difficulty in thinking than during 'low insulin' (p < 0.03). Results indicate an improving effect of insulin on cognitive function, and may provide a frame for further investigations of neurobehavioral effects of insulin in patients with lowered or enhanced brain insulin, i.e., patients with Alzheimer's disease or diabetes mellitus. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:52:55