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Titolo:
Phencyclidine-induced dysregulation of dopamine response to amphetamine inprefrontal cortex and striatum
Autore:
Balla, A; Hashim, A; Burch, S; Javitt, DC; Lajtha, A; Sershen, H;
Indirizzi:
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 8-9, volume: 26, anno: 2001,
pagine: 1001 - 1006
SICI:
0364-3190(200109)26:8-9<1001:PDODRT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR DOPAMINE; IN-VIVO; RELEASE; RAT; SCHIZOPHRENIA; INTERMITTENT; SEROTONIN; IMPAIRS; SINGLE; BASAL;
Keywords:
phencyclidine; schizophrenia; dopamine; amphetamine; prefrontal cortex; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Balla, A Nathan S Kline Inst Psychiat Res, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res 140 Old Orangeburg Rd Orangeburg NY USA 10962
Citazione:
A. Balla et al., "Phencyclidine-induced dysregulation of dopamine response to amphetamine inprefrontal cortex and striatum", NEUROCHEM R, 26(8-9), 2001, pp. 1001-1006

Abstract

Phencyclidine (PCP) administration in rodents has been used to model aspects of schizophrenia. One aspect of such treatment has been the enhancement of amphetamine-induced increase of dopamine in the prefrontal cortex and striatum. To further characterize this mechanism rats were treated for 2 weeks with continuous PCP (15 mg/kg per day via Alzet minipump). Rats were implanted with a microdialysis probe into the prefrontal cortex (PFC) or striatum. Amphetamine was administered locally via the dialysis probe during one collection period and changes in extracellular dopamine were monitored. Theeffect of local administration of the dopamine uptake blocker nomifensine was also measured. Amphetamine (10 muM) and nomifensine (10 muM) increased the level of dopamine in both the PFC and striatum. PCP administration did not alter the response to amphetamine or nomifensine in the PFC, but reduced this response about 2-fold in striatum. To examine effects of continuous PCP administration on dopamine autoreceptor function, release of [H-3]dopamine in response to electrical stimulation and in the presence of a dopamineagonist or antagonist was tested in striatal and prefrontal cortical tissue. Autoreceptor responses were similar in control and PCP-treated tissues. We conclude that the brain region-specific enhancement of dopamine release by peripheral amphetamine administration in rats after PCP is not likely mediated by alterations in the dopamine autoreceptors or changes in the dopamine transporter. The selective local responses of amphetamine indicates heterogeneous regional effects of continuous PCP on NMDA receptor function, effects that influence both regional excitatory responses and the overall dynamics of tonic excitatory/inhibitory inputs to the PFC and striatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:46:21