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Titolo:
Differential effect of nicotinic agonists on the [H-3]Norepinephrine release from rat hippocampal slices
Autore:
Kiss, JP; Windisch, K; De Oliveira, K; Hennings, ECP; Mike, A; Szasz, BK;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, H-1450 Budapest, Hungary Hungarian Acad Sci Budapest Hungary H-1450 col, H-1450 Budapest, Hungary
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 8-9, volume: 26, anno: 2001,
pagine: 943 - 950
SICI:
0364-3190(200109)26:8-9<943:DEONAO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; H-3 DOPAMINE RELEASE; ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; ION-CHANNEL; NORADRENALINE; LOBELINE; NOREPINEPHRINE; COMMUNICATION; INTERNEURONS;
Keywords:
nicotinic acetylcholine receptors; nicotine; DMPP; lobeline; carrier-mediated released; norepinephrine; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kiss, JP Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, POB 67, H-1450Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 apest, Hungary
Citazione:
J.P. Kiss et al., "Differential effect of nicotinic agonists on the [H-3]Norepinephrine release from rat hippocampal slices", NEUROCHEM R, 26(8-9), 2001, pp. 943-950

Abstract

The aim of this study was to investigate the mechanisms involved in the effect of nicotinic agonists on the [H-3]norepinephrine ([H-3]NE) release from rat hippocampal slices. The stimulatory effect of nicotine, cytisine, epibatidine and anatoxin-A was completely blocked by the nicotinic antagonist mecamylamine (10 muM). In contrast, the effect of dimethylphenylpiperazinium (DMPP) was only partially inhibited by mecamylamine but was completely blocked by the NE uptake inhibitor desipramine (DMI, 10 muM). Finally, the effect of lobeline was not affected by mecamylamine and was only partially blocked by DMI. Our data indicate that the majority of nicotinic agonists increase the release of [H-3]NE exclusively via stimulation of nicotinic acetylcholine receptors (nAChRs). DMPP, in addition to the stimulation of nAChRs, also evokes a carrier-mediated release. Lobeline has no stimulatory effect on nAChRs, induces a carrier-mediated release and has a further action ofunidentified mechanism. Our results suggest that special caution is required for the interpretation of data, when DMPP or lobeline are used as nicotinic agonists.

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Documento generato il 26/01/20 alle ore 22:09:56