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Titolo:
Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances
Autore:
Mody, I;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol RNRC 3 155, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 8-9, volume: 26, anno: 2001,
pagine: 907 - 913
SICI:
0364-3190(200109)26:8-9<907:DBGRRF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; CENTRAL-NERVOUS-SYSTEM; AMINOBUTYRIC ACID(A) RECEPTOR; SINGLE-CHANNEL PROPERTIES; DELTA-SUBUNIT; VOLUME TRANSMISSION; ALPHA-4 SUBUNIT; GABA(A)-RECEPTOR SUBTYPES; PYRAMIDAL NEURONS; RAT HIPPOCAMPUS;
Keywords:
GABA; inhibition; neuronal excitability; GABA(A) receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Mody, I Univ Calif Los Angeles, Sch Med, Dept Neurol RNRC 3 155, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
I. Mody, "Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances", NEUROCHEM R, 26(8-9), 2001, pp. 907-913

Abstract

Cell-to-cell communication in the mammalian nervous system does not solelyinvolve direct synaptic transmission. There is considerable evidence for atype of communication between neurons through chemical means that lies somewhere between the rapid synaptic information transfer and the relatively non-specific neuroendocrine secretion. Here I review some of the experimental evidence accumulated for the GABA system indicating that GABA(A) receptor-gated Cl-channels localized at synapses differ significantly from those found extrasynaptically. These two types of GABA(A) receptor are involved in generating distinctly different conductances. Thus, the development and search for pharmacological agents specifically aimed at selectively altering synaptic and extrasynaptic GABA(A) conductances is within reach, and is expected to provide novel insights into the regulation of neuronal excitability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 21:59:28