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Titolo:
Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction
Autore:
Strunsky, EG; Borisover, MD; Nikolsky, EE; Vyskocil, F;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 , Prague 4, Czech Republic Kazan State Med Univ, Kazan 140012, Russia Kazan State Med Univ Kazan Russia 140012 Med Univ, Kazan 140012, Russia Agr Res Org, Volcani Ctr, Inst Soils Water & Environm Sci, IL-50250 Bet Dagan, Israel Agr Res Org Bet Dagan Israel IL-50250 nm Sci, IL-50250 Bet Dagan, Israel Russian Acad Sci, Inst Biochem & Biophys, Kazan, Russia Russian Acad Sci Kazan Russia ci, Inst Biochem & Biophys, Kazan, Russia Charles Univ, Fac Sci, Dept Anim Physiol & Dev Biol, Prague 4, Czech Republic Charles Univ Prague Czech Republic 4 Dev Biol, Prague 4, Czech Republic
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 8-9, volume: 26, anno: 2001,
pagine: 891 - 897
SICI:
0364-3190(200109)26:8-9<891:TEOCDO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATE POTENTIAL FREQUENCY; ACETYLCHOLINE; DEPENDENCE; MODULATION; INHIBITION; KINETICS; MEMBRANE; SYNTHASE; FIBERS;
Keywords:
carbachol; temperature; acetylcholine release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Vyskocil, F Acad Sci Czech Republ, Inst Physiol, Videnska 1083, Prague 4, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 4c
Citazione:
E.G. Strunsky et al., "Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction", NEUROCHEM R, 26(8-9), 2001, pp. 891-897

Abstract

The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degreesC. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% andthe temperature dependence was negligible. However, an inverse temperaturedependence was found when low concentrations 3 x 10(-7) and 6 x 10(-7) M were applied. The depression of f was 40-50% in 5-10 degreesC but only 10-20% of the control in the 25 and 30 degreesC. During application of CCh, the new steady off was reached at temperatures between 5 and 30 degreesC within17-20 min (Q(10) = 1.07). Much greater temperature dependence of recovery was observed during washing out CCh (Q(10) = 1.6). The temperature-independence of the steady state effects of CCh, good agreement with Langmuir adsorption-desorption theory and non-steady kinetics indicate that physical rather than receptor-mediated events are responsible for the depression of f.

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Documento generato il 04/06/20 alle ore 01:21:39