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Titolo:
Potential role of endogenous brain-derived neurotrophic factor in long-term neuronal reorganization of the superior colliculus after bilateral visualdeprivation
Autore:
Vizuete, ML; Venero, JL; Vargas, C; Revuelta, M; Machado, A; Cano, J;
Indirizzi:
Univ Sevilla, Fac Farm, Dept Bioquim Bromatol & Toxicol, E-41012 Seville, Spain Univ Sevilla Seville Spain E-41012 tol & Toxicol, E-41012 Seville, Spain Univ Sevilla, Fac Farm, Dept Microbiol, E-41012 Seville, Spain Univ Sevilla Seville Spain E-41012 ept Microbiol, E-41012 Seville, Spain
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 866 - 880
SICI:
0969-9961(200110)8:5<866:PROEBN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; RECEPTOR ANTAGONISTS DISRUPT; D-ASPARTATE RECEPTOR; IN-VITRO; EYE ENUCLEATION; SUPRACHIASMATIC NUCLEUS; IMMUNOREACTIVE NEURONS; HIPPOCAMPAL-NEURONS; NMDA RECEPTORS; RAT;
Keywords:
BDNF; TrkB; NMDAR(1A); GAD(67); superior colliculus; synaptic zinc; synaptophysin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Vizuete, ML Univ Sevilla, Fac Farm, Dept Bioquim Bromatol & Toxicol, E-41012 Seville, Spain Univ Sevilla Seville Spain E-41012 l, E-41012 Seville, Spain
Citazione:
M.L. Vizuete et al., "Potential role of endogenous brain-derived neurotrophic factor in long-term neuronal reorganization of the superior colliculus after bilateral visualdeprivation", NEUROBIOL D, 8(5), 2001, pp. 866-880

Abstract

The role of the brain-derived neurotrophic factor (BDNF), the BDNF receptor (TrkB), and the glutamic acid decarboxylase (GAD(67)) after neonatal, bilateral nerve deafferentiation during postnatal development was investigatedin the rat superior colliculus (SC). BDNF and GAD(67) mRNA expression weresignificantly increased in optic (Op) and intermediate gray (InG) layers at 5, 8, 15, and 21 days after birth, but not in adult animals. However, TrkB mRNA expression was not modified at any time tested. At 15 days, where changes in BDNF and GAD(67) mRNAs were more evident, an upregulation of the NMDAR(1A) mRNA glutamate receptor in the Op and InG, a modification in the pattern of synaptic zinc in the superficial layers of SC, and an increased synaptophysin immunoreactivity in the Op was found. This indicates the existence of a synergic mechanism between BDNF and NMDA to determine refinement of connections after the loss of visual input in SC. (C) 2001 Academic Press.

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Documento generato il 20/01/20 alle ore 22:05:04