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Titolo:
Impaired glutamate uptake in the R6 Huntington's disease transgenic mice
Autore:
Lievens, JC; Woodman, B; Mahal, A; Spasic-Boscovic, O; Samuel, D; Goff, LKL; Bates, GP;
Indirizzi:
GKT Sch Med, Med & Mol Genet, London, England GKT Sch Med London England KT Sch Med, Med & Mol Genet, London, England Lab Neurobiol Cellulaire & Fonctionnelle, CNRS, Marseille, France Lab Neurobiol Cellulaire & Fonctionnelle Marseille France eille, France
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 807 - 821
SICI:
0969-9961(200110)8:5<807:IGUITR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; MESSENGER-RNA EXPRESSION; NEURONAL INTRANUCLEAR INCLUSIONS; RAT CEREBRAL-CORTEX; HIGH-AFFINITY; MOUSE MODELS; COMPARATIVE IMMUNOCYTOCHEMISTRY; MUTANT HUNTINGTIN; TRANSPORTER GLT-1; STRIATAL NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Lievens, JC GKT Sch Med, Med & Mol Genet, London, England GKT Sch Med London England Med & Mol Genet, London, England
Citazione:
J.C. Lievens et al., "Impaired glutamate uptake in the R6 Huntington's disease transgenic mice", NEUROBIOL D, 8(5), 2001, pp. 807-821

Abstract

Huntington's disease (HD) is a late-onset neurodegenerative disease for which the mutation is CAG/polyglutamine repeat expansion. The R6 mouse lines expressing the HD mutation develop a movement disorder that is preceded by the formation of neuronal polyglutamine aggregates. The phenotype is likelycaused by a widespread neuronal dysfunction, whereas neuronal cell death occurs late and is very selective. We show that a decreased mRNA level of the major astroglial glutamate transporter (GLT1) in the striatum and cortex of these mice is accompanied by a concomitant decrease in glutamate uptake. In contrast, the expression of the glutamate transporters, GLAST and EAAC1, remain unchanged. The mRNA level of the astroglial enzyme glutamine synthetase is also decreased. These changes in expression occur prior to any evidence of neurodegeneration and suggest that a defect in astrocytic glutamate uptake may contribute to the phenotype and neuronal cell death in HD. (C)2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:53:58