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Titolo:
Oxidation of a beta and plaque biogenesis in Alzheimer's disease and Down syndrome
Autore:
Head, E; Garzon-Rodriguez, W; Johnson, JK; Lott, IT; Cotman, CW; Glabe, C;
Indirizzi:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ng & Dementia, Irvine, CA 92697 USA Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol & Biochem, Irvine, CA 92697 USA Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico Univ Calif Irvine, Dept Pediat, Mental Retardat Ctr, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Retardat Ctr, Irvine, CA 92697 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 792 - 806
SICI:
0969-9961(200110)8:5<792:OOABAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; INTRACELLULAR ACCUMULATION; TERMINAL HETEROGENEITY; AGGREGATION PROPERTIES; SCAVENGER RECEPTOR; TRANSFECTED CELLS; MICROGLIAL CELLS; SENILE PLAQUES; BRAIN-TISSUE; IN-VITRO;
Keywords:
Alzheimer's disease; amyloid; brain aging; canine; Down syndrome; microglia; oxidative damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Head, E Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 entia, Irvine, CA 92697 USA
Citazione:
E. Head et al., "Oxidation of a beta and plaque biogenesis in Alzheimer's disease and Down syndrome", NEUROBIOL D, 8(5), 2001, pp. 792-806

Abstract

The processes involved with beta -amyloid (A beta) degradation and clearance in human brain are not well understood. We hypothesized that the distribution of oxidatively modified A beta, as determined by an affinity-purifiedantibody in the entorhinal and frontal cortices of Alzheimer's disease (AD), Down syndrome (DS), nondemented elderly control cases, and canine brain,would provide insight into the mechanisms of A beta accumulation. Based upon plaque counts, oxidized A beta was present within 46-48% of diffuse and primitive plaques and 98% of cored plaques. Dense punctate deposits of oxidized A beta were distributed throughout the neuropil in AD and DS brains but were also present within controls with mild neuropathology and isolated cognitive impairments. Confocal studies indicate that punctate oxidized A beta deposits were within activated microglia. Oxidatively modified A beta may reflect the efforts of microglial cells to take up and degrade A beta. Oxidative modification of A beta may be an early event in A beta pathogenesisand may be important for plaque biogenesis. (C) 2001 Academic Press.

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Documento generato il 23/01/20 alle ore 12:46:32