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Titolo:
Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex
Autore:
Akbarian, S; Chen, RZ; Gribnau, J; Rasmussen, TP; Fong, HF; Jaenisch, R; Jones, EG;
Indirizzi:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA MIT, Dept Biol, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142MIT, Dept Biol, Cambridge, MA 02142 USA Univ Calif Davis, Ctr Neurosci, Livermore, CA 95616 USA Univ Calif Davis Livermore CA USA 95616 Neurosci, Livermore, CA 95616 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 784 - 791
SICI:
0969-9961(200110)8:5<784:EPOTRS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CPG-BINDING PROTEIN-2; HISTONE MACROH2A1; MUTATIONS; NEURONS; BRAIN; METHYLATION; CHROMOSOME; NEOCORTEX; CELLS;
Keywords:
transcriptional repression; gene silencing; DNA methylation; Old World monkey; Macaca mulatta; frontal lobe; autism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Akbarian, S Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA USA 02142
Citazione:
S. Akbarian et al., "Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex", NEUROBIOL D, 8(5), 2001, pp. 784-791

Abstract

Dysfunction of the prefrontal cortex may contribute to the autistic features and mental retardation of Rett syndrome, a neuropsychiatric condition caused by mutations of the gene encoding methyl-CpG-binding protein 2 (MeCP2). Because nothing is known about the expression of MeCP2 and other chromatin-associated factors in primate brain, we studied in monkey prefrontal cortex and murine cerebral cortex expression patterns of MeCP2 and of macrohistone H2A (MacroH2A), which like MeCP2 is associated with transcriptionally silent chromatin. In both species, MeCP2 and MacroH2A appeared to be ubiquitously expressed by cortical neurons, including projection neurons and GABAergic interneurons. In the adult monkey, MeCP2 expression was robust throughout all layers of the prefrontal cortex but it was limited in fetal monkeysat embryonic day 110 to the deeper cortical layers and the subplate. Theseresults suggest that MeCP2 may be important for neuronal maintenance in the developing and in the mature primate prefrontal cortex, consistent with the previously reported phenotype of MeCP2-null mutant mice. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:35:31