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Titolo:
Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability
Autore:
Costa, E; Davis, J; Grayson, DR; Guidotti, A; Pappas, GD; Pesold, C;
Indirizzi:
Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Dept Psychiat, Chicago, IL 60612 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 723 - 742
SICI:
0969-9961(200110)8:5<723:DSHADO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; CORTICAL PYRAMIDAL NEURONS; MESSENGER-RNA EXPRESSION; HUMAN CEREBRAL-CORTEX; PROTEIN-SYNTHESIS; PREFRONTAL CORTEX; BIPOLAR DISORDER; GENE-EXPRESSION; MOLECULAR CHARACTERIZATION; STRUCTURAL ABNORMALITIES;
Keywords:
reelin; schizophrenia; bipolar disorder; psychosis; dendritic spines; GAD(67); reeler heterozygote; integrin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Costa, E Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 ychiat, Chicago, IL 60612 USA
Citazione:
E. Costa et al., "Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability", NEUROBIOL D, 8(5), 2001, pp. 723-742

Abstract

In this review, we will first present a brief overview of the current understanding of: (a) the biology of reelin; (b) the putative reelin signaling pathways via integrin receptor stimulation; (c) the cytosolic adapter protein DAB1, which appears to be operative in the transduction of reelin's pleiotropic actions in embryonic, adolescent, and adult brain; (d) the regulation of GABAergic function, including some aspects of GABAergic system development; and (e) dendritic spine function and its role in the regulation of synaptic plasticity. We argue that a downregulation of reelin expression occurring in prefrontal cortex and in every brain structure of schizophrenia patients so far studied may be associated with a decrease in dendritic spineexpression that in turn may provide an important reduction of cortical function as documented by the downregulation of glutamic acid decarboxylases, (GAD(67)) expression, which might be secondary to a reduction:of GABAergic axon terminals. This hypothesis is supported by a genetic mouse model of reelin haploinsufficiency that replicates the above-described dendritic and presynaptic GABAergic defects documented in schizophrenia brains. (C) 2001 Academic Press.

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Documento generato il 05/04/20 alle ore 09:30:38