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Titolo:
Associations of micro-albuminuria with intra-uterine growth retardation
Autore:
Yudkin, JS; Martyn, CN; Phillips, DIW; Gale, CR;
Indirizzi:
Univ Coll London, London WC1E 6BT, England Univ Coll London London England WC1E 6BT ondon, London WC1E 6BT, England Univ Southampton, MRC, Environm Epidemiol Unit, Southampton SO9 5NH, Hants, England Univ Southampton Southampton Hants England SO9 5NH O9 5NH, Hants, England
Titolo Testata:
NEPHRON
fascicolo: 3, volume: 89, anno: 2001,
pagine: 309 - 314
SICI:
0028-2766(200111)89:3<309:AOMWIG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CORONARY HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; LOW-BIRTH-WEIGHT; NONDIABETIC SUBJECTS; INSULIN-RESISTANCE; RENAL-DISEASE; ADULT LIFE; GLUCOSE-TOLERANCE; VASCULAR-DISEASE;
Keywords:
micro-albuminuria; cardiovascular risk; programming; intra-uterine growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yudkin, JS Univ Coll London, Whittington Hosp, Dept Med, Holborn Union Bldg,Archway Wing,Archway Rd, London N19 3UA, England Univ Coll London HolbornUnion Bldg,Archway Wing,Archway Rd London England N19 3UA
Citazione:
J.S. Yudkin et al., "Associations of micro-albuminuria with intra-uterine growth retardation", NEPHRON, 89(3), 2001, pp. 309-314

Abstract

Background/Aim: Micro-albuminuria is associated with insulin resistance and a high blood pressure and predicts an increased risk of cardiovascular disease in both diabetic and non-diabetic populations. Relationships have been described for micro-albuminuria with both low birth weight and short stature in adulthood. We have tested the hypothesis that micro-albuminuria in non-diabetic adults may be associated with markers of intrauterine growth retardation. Methods: We measured the urinary albumin excretion rate in 818 men and women from three populations, in whom detailed records of birth weight were available, of whom 354 had records of length at birth to provide anestimate of the ponderal index. Results: The albumin excretion rates were higher in men than in women (5.1 vs. 3.8 mug/min) and were related to age (r = 0.23, p < 0.001) and body mass index (r = 0.08, p = 0.02) as well as fasting plasma glucose and blood pressure. Considered as a continuous variable, the albumin excretion rate was not related to any measure of size at birth or to adult height. Fifty-four subjects (6.6%) were micro-albuminuric (albumin excretion rate greater than or equal to 20 mug/ min), and these subjects were thinner at birth than normo-albuminuric subjects (12.9 vs. 13.8 oz/in(3), p = 0.09). Compared to those subjects whose ponderal index had been in the upper third of the distribution, people whose ponderal index had been in the lower third of the distribution had an odds ratio for micro-albuminuria of 3.1 (p for trend 0.05). Conclusion: The association between micro-albuminuria, insulin resistance, and coronary heart disease may be a consequence of growth retardation representing a common antecedent. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:25:52