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Titolo:
Evolution pattern of auto-antibodies against oxidized low-density lipoproteins in renal transplant recipients
Autore:
Kandoussi, AM; Glowacki, F; Duriez, P; Tacquet, A; Fruchart, JC; Noel, C;
Indirizzi:
Inst Pasteur, Inserm U 325, F-59019 Lille, France Inst Pasteur Lille France F-59019 r, Inserm U 325, F-59019 Lille, France Hop Calmette, Clin Nephrol A, Lille, France Hop Calmette Lille FranceHop Calmette, Clin Nephrol A, Lille, France
Titolo Testata:
NEPHRON
fascicolo: 3, volume: 89, anno: 2001,
pagine: 303 - 308
SICI:
0028-2766(200111)89:3<303:EPOAAO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVELY-MODIFIED LDL; CHRONIC REJECTION; CYCLOSPORINE-A; AUTOANTIBODIES; DISEASE; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; SUSCEPTIBILITY; OXIDIZABILITY; INCREASES;
Keywords:
malondialdehyde-modified low-density lipoprotein; Cu2+-oxidized low-density lipoprotein; auto-antibody; ciclosporin A; lag phase; renal transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kandoussi, AM Inst Pasteur, Inserm U 325, POB 245, F-59019 Lille, France Inst Pasteur POB 245 Lille France F-59019 019 Lille, France
Citazione:
A.M. Kandoussi et al., "Evolution pattern of auto-antibodies against oxidized low-density lipoproteins in renal transplant recipients", NEPHRON, 89(3), 2001, pp. 303-308

Abstract

An increased degree of oxidative stress in renal transplant recipients anda possible role of ciclosporin A (Cs-A) immunosuppressive therapy in this process have already been described. However, prospective data using in vivo markers and the influence of Cs-A in the oxidizability of low-density lipoprotein (LDL) are scarce. We aimed at investigating in this prospective study the evolution pattern of auto-antibodies directed against malondialdehyde-modified LDL (MDA-LDL) and Cu2+-oxidized LDL in 28 stable renal transplant recipients on Cs-A immunosuppressive therapy before and after 3 successive years of renal transplantation. Also, the effect of enrichment of LDL with Cs-A on the susceptibility of LDL to in vitro oxidation was tested. The results showed a significant increase of both auto-antibody titres (MDA-LDLand Cu2+-oxidized LDL) after 1 year, and the values remained high during the 2nd and the 3rd year following transplantation. The yearly mean relativevariations of auto-antibodies against MDA-LDL and Cu2+-oxidized LDL duringthe follow-up period were 133, 149, and 137%, and 111, 115, and 117%, respectively. A significant correlation was observed during the 1st year between Cs-A trough blood level and Cu2+-oxidized LDL auto-antibody: r = 0.04 (p = 0.046). Incorporation of Cs-A into LDL from healthy volunteers showed no changes during the lag phase in comparison with Cs-A-free LDL, indicating that Cs-A had no effect on in vitro LDL oxidizability. Our results suggest that Cs-A may be involved earlier in the LDL oxidation, but the mechanism bywhich it acts is still unclear. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 08:01:03