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Titolo:
Early prediction of a benign course of multiple sclerosis on clinical grounds: a systematic review
Autore:
Ramsaransing, G; Maurits, N; Zwanikken, C; De Keyser, J;
Indirizzi:
Acad Hosp Groningen, Dept Neurol, NL-9700 RB Groningen, Netherlands Acad Hosp Groningen Groningen Netherlands NL-9700 RB ningen, Netherlands
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 5, volume: 7, anno: 2001,
pagine: 345 - 347
SICI:
1352-4585(200110)7:5<345:EPOABC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; FOLLOW-UP; PROGNOSIS; DEMYELINATION; MRI;
Keywords:
multiple sclerosis; benign; outcome; systematic review; EDSS; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ramsaransing, G Acad Hosp Groningen, Dept Neurol, POB 30-001, NL-9700 RB Groningen, Netherlands Acad Hosp Groningen POB 30-001 Groningen NetherlandsNL-9700 RB
Citazione:
G. Ramsaransing et al., "Early prediction of a benign course of multiple sclerosis on clinical grounds: a systematic review", MULT SCLER, 7(5), 2001, pp. 345-347

Abstract

Background. There is growing consensus that neurologists should consider disease-modifying therapies early in multiple sclerosis (MS). However there is a subgroup with a natural benign course, in which treatment could be postponed. We sought to determine the frequency of benign MS and early clinical factors that may predict a benign course. Methods: We performed a systematic review of the existing literature on benign MS, which was defined as minimal or no disability equivalent to a score on the Expanded Disability Status Scale (EDSS) less than or equal to 3.0 at least 10 years after disease onset. Results: Only a small number of studies of adequate quality was available. In total there were nine published studies representing 2204 patients. The estimated frequency of benign MS was 26.7%. Onset with optic neuritis, onset before the age of 40 years, absence of pyramidal signs at presentation, duration of first remission more than I year, and only one exacerbation in the first 5 years after onset of MS, were associated with a benign course, Conclusions: From the existing literature a set of unrelated clinicalcharacteristics emerged that was associated with a benign course of MS. However, there is a need for prospective studies to define more precisely clinical and paraclinical predictors of benign MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:07:08