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Titolo:
Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat
Autore:
Deransart, C; Landwehrmeyer, GB; Feuerstein, TJ; Lucking, CH;
Indirizzi:
Klinikum Univ Freiburg, Neurozentrum, Sekt Klin Neuropharmakol, D-79106 Freiburg, Germany Klinikum Univ Freiburg Freiburg Germany D-79106 -79106 Freiburg, Germany Univ Ulm, Uniklinikum, Neurol Poliklin, D-89075 Ulm, Germany Univ Ulm Ulm Germany D-89075 ikum, Neurol Poliklin, D-89075 Ulm, Germany
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 94, anno: 2001,
pagine: 166 - 177
SICI:
0169-328X(20011019)94:1-2<166:UODDRM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE MESSENGER-RNA; INSITU HYBRIDIZATION HISTOCHEMISTRY; IN-SITU HYBRIDIZATION; FREELY MOVING RATS; MAL-LIKE SEIZURES; D-3 RECEPTOR; BASAL GANGLIA; MOLECULAR-CLONING; SUBSTANTIA-NIGRA; EXPRESSION;
Keywords:
absence-epilepsy; basal ganglia; dopamine; genetic model; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Deransart, C Klinikum Univ Freiburg, Neurozentrum, Sekt Klin Neuropharmakol, Breisacherstr 64, D-79106 Freiburg, Germany Klinikum Univ Freiburg Breisacherstr 64 Freiburg Germany D-79106
Citazione:
C. Deransart et al., "Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat", MOL BRAIN R, 94(1-2), 2001, pp. 166-177

Abstract

The basal ganglia system is thought to play a key role in the control of absence-seizures and there is ample evidence that epileptic seizures modify brain dopamine function. We recently reported that local injections of dopamine DI or D2 agonists in the core of the nucleus accumbens suppressed absence-seizures in a spontaneous, genetic rodent model of absence-epilepsy whereas injections of DI or D2 antagonists had aggravating effects. These findings raised the possibility that the dopaminergic system may be altered in absence-epilepsy prone rats. Therefore, we studied by in situ hybridizationhistochemistry the expression of pre- and postsynaptic components of the dopaminergic system in this strain of rats. When compared to non-epileptic control rats, epileptic rats displayed no change in the expression of mRNAs coding for the neuronal dopaminergic markers (tyrosine hydroxylase, membraneous and vesicular dopamine transporters). In addition, there was no difference between the two strains concerning the expression of the dopamine receptor transcripts DI, D2 and D5. In adult absence-epilepsy prone rat with anovert epileptic phenotype, however, an elevated level of D3 mRNA expression was observed in neurons of the core of the nucleus accumbens (+23% increase in silver grain density compared to non-epileptic control rats). D3 transcripts were not increased in juvenile epileptic rats without seizures. These findings suggests that up-regulation of D3 receptor mRNA is part of the epileptic phenotype in absence-epilepsy prone rats. Its localization in thecore of the nucleus accumbens bears close resemblance to the dopamine-sensitive antiepileptic sites in ventral striatum and further support the involvement of ventral structures of the basal ganglia system in the control of absence-seizures. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:30:26