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Titolo:
Acute ethanol administration differentially modulates mu opioid receptors in the rat meso-accumbens and mesocortical pathways
Autore:
Mendez, M; Leriche, M; Calva, JC;
Indirizzi:
Inst Nacl Psiquiatria Ramon Fuente Muniz, Subdirecc Invest Clin, Mexico City 14370, DF, Mexico Inst Nacl Psiquiatria Ramon Fuente Muniz Mexico City DF Mexico 14370 xico
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 94, anno: 2001,
pagine: 148 - 156
SICI:
0169-328X(20011019)94:1-2<148:AEADMM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING AA; NG108-15 HYBRID-CELLS; PITUITARY BETA-ENDORPHIN; FREELY MOVING RATS; AVOIDING ANA RATS; OPIATE RECEPTORS; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; DOWN-REGULATION; EXTRACELLULAR DOPAMINE;
Keywords:
alcohol brain reinforcement mechanism; endogenous opioid system; mu opioid receptor; dopaminergic mesolimbic system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Mendez, M Inst Nacl Psiquiatria Ramon Fuente Muniz, Subdirecc Invest Clin,Calzada Mexico Xochimilco 101,Col San Lorenzo Hui, Mexico City 14370, DF, Mexico Inst Nacl Psiquiatria Ramon Fuente Muniz Calzada Mexico Xochimilco 101,Col San Lorenzo Hui Mexico City DF Mexico 14370
Citazione:
M. Mendez et al., "Acute ethanol administration differentially modulates mu opioid receptors in the rat meso-accumbens and mesocortical pathways", MOL BRAIN R, 94(1-2), 2001, pp. 148-156

Abstract

Biochemical and pharmacological evidence suggest that the dopaminergic mesolimbic system plays a key role in mediating the reinforcing properties of alcohol and other drugs of abuse. Alcohol reinforcement and high alcohol drinking behavior have been postulated to be partially mediated by a neurobiological mechanism involving the alcohol-induced activation of the endogenous opioid system. The aim of this work was to study the effect of the in vivo acute administration of ethanol on mu (mu) opioid receptors in the rat dopaminergic meso-accumbens and mesocortical pathways by quantitative receptor auto radiography. [H-3]DAMGO binding was significantly decreased in the ventral tegmental area (VTA) 30 min after ethanol administration. A small ethanol-induced reduction was observed in the shell region of the nucleus accumbens 1 It after exposure. In contrast, 2 h after ethanol administration, [H-3]DAMGO binding was significantly increased in the frontal and prefrontal cortices. The observed changes correlated well with high ethanol plasma levels. Our results suggest that the reinforcing properties of ethanol may be partially mediated by mechanisms involving the ethanol-induced down- and up-regulation of L receptors in the dopaminergic mesolimbic system. Mu receptors in the VTA and the frontal and prefrontal cortices may be involved inthe in vivo acute responses to ethanol and could play a key role in modulating the dopaminergic activity of the mesocortical pathway in response to the drug. In contrast, the contribution of both mu and 8 receptors in the nucleus accumbens might be relevant in these processes. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:03:50