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Titolo:
Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients
Autore:
Granot, E; Shouval, D; Ashur, Y;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Univ Hosp, Hadassah Med Sch, Pediat Dept,Pediat Gastroenterol Unit, IL-91120 Jerusalem, Israel Hebrew Univ JerusalemJerusalem Israel IL-91120 -91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Univ Hosp, Hadassah Med Sch, Liver Unit, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120-91120 Jerusalem, Israel
Titolo Testata:
MEDIATORS OF INFLAMMATION
fascicolo: 5, volume: 10, anno: 2001,
pagine: 253 - 258
SICI:
0962-9351(200110)10:5<253:CAMAHA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOLOGICAL ACTIVITY; INTERFERON TREATMENT; SCORING SYSTEM; LIVER-DISEASE; SERUM LEVELS; EXPRESSION; REFLECTS; VIRUS;
Keywords:
HCV; therapy; ICAM-1; VCAM-1; hyaluronic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Granot, E Hebrew Univ Jerusalem, Hadassah Univ Hosp, Hadassah Med Sch, Pediat Dept,Pediat Gastroenterol Unit, POB 12000, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem POB 12000 Jerusalem Israel IL-91120 srael
Citazione:
E. Granot et al., "Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients", MEDIAT INFL, 10(5), 2001, pp. 253-258

Abstract

Objective: Cell adhesion molecules (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) and hyaluronic acid, markers of inflammation and fibrosis were monitored in hepatitis C patients to determine whether changes in plasma levels, during antiviral treatment, canpredict long-term response to therapy. Methods: In 55 patients with chronic hepatitis C virus (HCV), 33 treated with interferon (IFN) and 22 treated with IFN + ribavirin, sera was collected prior to treatment, at 3 + 6 months of therapy and 6 months post-treatment. Levels of ICAM-1, VCAM-1 and hyaluronic acid were correlated with alanine aminotransferase levels, HCV-RNA-polymerase chain reaction status and histological fibrosis scoring. Results: A decrease in ICAM-1 levels at 3 and 6 months of therapy, compared with pretreatment levels, was observed in responders to IFN + ribavirin therapy but this decrease in ICAM-1 levels was not evident following cessation of treatment. Hyaluronic acid levels, in both treatment groups, did not differ significantly between responders and non-responders. Hyaluronic acidlevels did correlate, significantly, with degree of fibrosis whereas VCAM-1 levels were marginally increased only in patients with moderate (grade III) fibrosis. Conclusions: Monitoring of VCAM-1 and hyaluronic acid, during antiviral therapy, does not differentiate between responders and non-responders. A decrease in ICAM-1 levels during IFN + ribavirin treatment is associated with response to therapy, and its efficacy in predicting long-term response should be further substantiated.

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Documento generato il 06/07/20 alle ore 04:57:42