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Titolo:
Age-related changes of dopamine receptors in the rat hippocampus: a light microscope autoradiography study
Autore:
Amenta, F; Mignini, F; Ricci, A; Sabbatini, M; Tomassoni, D; Tayebati, SK;
Indirizzi:
Univ Camerino, Dipartimento Sci Farmacol & Med Sperimentale, Sez Anat Umana, I-62032 Camerino, Italy Univ Camerino Camerino Italy I-62032 Anat Umana, I-62032 Camerino, Italy Univ Roma La Sapienza, Dipartimento Sci Cardiovasc & Resp, I-00161 Rome, Italy Univ Roma La Sapienza Rome Italy I-00161 asc & Resp, I-00161 Rome, Italy
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 16, volume: 122, anno: 2001,
pagine: 2071 - 2083
SICI:
0047-6374(200111)122:16<2071:ACODRI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; HUMAN-BRAIN; ACETYLCHOLINE-RELEASE; D-2-LIKE RECEPTORS; MOLECULAR-BIOLOGY; MESSENGER-RNAS; D1; LOCALIZATION; D2; SYSTEM;
Keywords:
hippocampus; dopamine D1-like receptors; dopamine D2-like receptors; ageing; autoradiography; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Amenta, F Univ Camerino, Dipartimento Sci Farmacol & Med Sperimentale, SezAnat Umana, Via Scalzino,3, I-62032 Camerino, Italy Univ Camerino Via Scalzino,3 Camerino Italy I-62032 rino, Italy
Citazione:
F. Amenta et al., "Age-related changes of dopamine receptors in the rat hippocampus: a light microscope autoradiography study", MECH AGE D, 122(16), 2001, pp. 2071-2083

Abstract

Hippocampus is a brain region involved in learning and memory and is particularly sensitive to ageing. It is supplied with a dopaminergic innervationarising from the midbrain, which is part of the mesolimbic dopaminergic pathway. Dysfunction of the dopaminergic mesolimbic system is probably involved in the pathophysiology of psychosis and behavioural disturbances occurring in the elderly. The present study was designed to assess the density andlocalisation of dopamine D1- and D2-like receptor subtypes in the hippocampus of male Sprague-Dawley rats aged 3 months (young), 12 months (adult) and 24 months (old). Dopamine D1-like receptors, labelled by [H-3]-SCH 23390,in young rats displayed a dentate gyrus-CA1 subfield gradient. The expression was increased in the cell body of dentate gyrus, CA4 and CA3 subfield of old rats compared to younger cohorts, as well as in the neuropil of dentate gyrus. A decreased density of dopamine D1-like receptors was found in the stratum oriens of CA1 and CA3 subfields. Dopamine D2-like receptors, labelled using [H-3]-spiperone as radioligand, were expressed rather homogeneously throughout different subfields of the hippocampus. In old rats, the density of dopamine D2-like receptors was decreased in the dentate gyrus, unchanged in the CA4 and CA1 subfields. and increased in the CA3 subfield. The above results indicate the occurrence of inhomogeneous changes in the density of dopamine D1- and D2-like receptors in specific portions of hippocampus of old rats. These findings support the hypothesis of an involvement of dopaminergic system in behavioural abnormalities or psychosis occurring in ageing. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:42:22