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Titolo:
Inflammatory markers in Alzheimer's disease and multi-infarct dementia
Autore:
De Luigi, A; Fragiacomo, C; Lucca, U; Quadri, P; Tettamanti, M; De Simoni, MG;
Indirizzi:
Mario Negri Inst Pharmacol Res, Dept Neurosci, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Beata Vergine Reg Hosp, Div Geriatr, Mendrisio, Switzerland Beata Vergine Reg Hosp Mendrisio Switzerland tr, Mendrisio, Switzerland
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 16, volume: 122, anno: 2001,
pagine: 1985 - 1995
SICI:
0047-6374(200111)122:16<1985:IMIADA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; INTERLEUKIN-6 INDUCTION; VASCULAR DEMENTIA; BRAIN; SYSTEM; PATTERNS;
Keywords:
Alzheimer's disease; multi-infarct dementia; inflammatory cytokines; antiinflammatory cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: De Simoni, MG Mario Negri Inst Pharmacol Res, Dept Neurosci, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
A. De Luigi et al., "Inflammatory markers in Alzheimer's disease and multi-infarct dementia", MECH AGE D, 122(16), 2001, pp. 1985-1995

Abstract

Inflammation has been involved in the pathogenesis of dementia. The study evaluates the presence and the source of pro- and anti-inflammatory cytokines in the blood of patients with Alzheimer's disease (AD), multi-infarct dementia (MID) or in non-demented elderly people (controls). Tumor necrosis factor (TNF)-alpha interleukin (IL)-l beta, IL-6, IL-10, IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor I (sTNF-RI) plasma concentrations and release from blood cells stimulated with lipopolysaccharide (LPS, 1 mug/ml) were determined. The results show that TNF-alpha released from blood cells is significantly decreased (27%) in all demented patients compared to controls. Circulating TNF-alpha is increased (400%) only in MID patients. Inthese patients plasma levels of sTNF-RI are increased (53%) and IL-10 fromstimulated blood cells decreased (47%) compared to non-demented subjects. The results show that: (1) peripheral production of TNF-alpha is blunted indemented (both AD and MID) patients compared to non-demented age-matched subjects; (2) AD patients have a selective disregulation of the peripheral TNF-alpha system; (3) different cytokines are up- or down- regulated in MID patients showing that in this condition the pro- and anti-inflammatory peripheral cytokine system is more widely affected. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:33:30