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Titolo:
Pathophysiological aspects of frontotemporal dementia - emphasis on cytoskeleton proteins and autoimmunity
Autore:
Sjogren, M; Wallin, A;
Indirizzi:
Univ Gothenburg, Sahlgrens Univ Hosp, Psychiat Sect, Inst ClinNeurosci, SE-43180 Molndal, Sweden Univ Gothenburg Molndal Sweden SE-43180 urosci, SE-43180 Molndal, Sweden
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 16, volume: 122, anno: 2001,
pagine: 1923 - 1935
SICI:
0047-6374(200111)122:16<1923:PAOFD->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE DEGENERATION; NON-ALZHEIMER TYPE; CEREBROSPINAL-FLUID; TAU-PROTEIN; NEURODEGENERATIVE DISEASES; ANTIINFLAMMATORY DRUGS; NEUROLOGICAL DISORDERS; BALLOONED NEURONS; CLINICAL PICTURE; MUTATIONS;
Keywords:
frontotemporal dementia; cerebrospinal fluid; tau; neurofilament protein; gangliosides; sulfatides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Sjogren, M Univ Gothenburg, Sahlgrens Univ Hosp, Psychiat Sect, Inst ClinNeurosci, SE-43180 Molndal, Sweden Univ Gothenburg Molndal Sweden SE-4318043180 Molndal, Sweden
Citazione:
M. Sjogren e A. Wallin, "Pathophysiological aspects of frontotemporal dementia - emphasis on cytoskeleton proteins and autoimmunity", MECH AGE D, 122(16), 2001, pp. 1923-1935

Abstract

The aim of this study was to investigate two putative pathophysiological aspects of the common neurodegenerative disorder frontotemporal dementia (FTD). To this end, cerebrospinal fluid (CSF) levels of tau (total tau) and the light subtype of the neurofilament proteins (NFL) were studied in patients with FTD (n = 16) and in age-matched controls (n = 16). In addition, serum was analysed for IgG and IgM antibodies to the most common gangliosides and sulfatide in FTD patients (n = 13) and in age-matched controls (n = 20). The CSF-NFL levels were increased in FTD (1606 +/- 1151 pg/ml, mean +/- S.D.; P < 0.001) compared with controls (308 +/- 203 pg/ml), whereas the CSF-tau levels were normal. In serum, autoantibody IgG-GA1 was significantly increased in FTD (P < 0.05) compared with controls. No correlations were found between the effect parameters and demographic variables in any group. Theresults of this study suggest that cytoskeleton proteins other than tau are also involved in the pathophysiology of FTD and that autoimmunity may be part of the pathophysiological processes in FTD, as it is believed to be inAlzheimer's disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:18:16