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Titolo:
Use of spin echo T-2 BOLD in assessment of cerebral misery perfusion at 1.5 T
Autore:
Kavec, M; Grohn, OHJ; Kettunen, MI; Silvennoinen, MJ; Penttonen, M; Kauppinen, RA;
Indirizzi:
Univ Kuopio, AI Virtanen Inst, Natl Bio NMR Facil, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 MR Facil, FIN-70211 Kuopio, Finland Univ Kuopio, AI Virtanen Inst, Cognit Neurobiol Lab, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 biol Lab, FIN-70211 Kuopio, Finland
Titolo Testata:
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
fascicolo: 1, volume: 12, anno: 2001,
pagine: 32 - 39
SICI:
0968-5243(200103)12:1<32:UOSETB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NUCLEAR-MAGNETIC-RESONANCE; TRANSIENT FOREBRAIN ISCHEMIA; BLOOD-FLOW; CEREBROVASCULAR-DISEASE; OXYGEN EXTRACTION; RELAXATION-TIME; HUMAN BRAIN; CLINICAL-APPLICATIONS; REVERSIBLE ISCHEMIA;
Keywords:
brain; misery perfusion; ischaemia; BOLD; spin echo; oxygen extraction; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kavec, M Univ Kuopio, AI Virtanen Inst, Natl Bio NMR Facil, Neulaniementie2,POB 1627, FIN-70211 Kuopio, Finland Univ Kuopio Neulaniementie 2,POB 1627 Kuopio Finland FIN-70211 d
Citazione:
M. Kavec et al., "Use of spin echo T-2 BOLD in assessment of cerebral misery perfusion at 1.5 T", MAGN RES MA, 12(1), 2001, pp. 32-39

Abstract

Inadequate blood supply relative to metabolic demand, a haemodynamic condition termed as misery perfusion, often occurs in conjunction with acute ischaemic stroke. Misery perfusion results in adaptive changes in cerebral physiology including increased cerebral blood volume (CBV) and oxygen extraction ratio (OER) to secure substrate supply for the brain. It has been suggested that the presence of misery perfusion may be an indication of reversible ischaemia, thus detection of this condition may have clinical impact in acute stroke imaging. The ability of single spin echo T-2 to detect misery perfusion in the rat brain at 1.5 T owing to its sensitivity to blood oxygenation level dependent (BOLD) contrast was studied both theoretically and experimentally. Based on the known physiology of misery perfusion, tissue morphometry and blood relaxation data. T, behaviour in misery perfusion was simulated. The interpretation of these computations was experimentally assessed by quantifying T, in a rat model for cerebral misery perfusion. CBF was quantified with the H-2 clearance method. A drop of CBF from 58 +/- 8 to 17+/- 3 ml/100 g/min in the parieto-frontal cortex caused shortening of T-2 from 66.9 +/- 0.4 to 64.6 +/- 0.5 ms. Under these conditions, no change in diffusion MRI was detected. In contrast, the cortex with CBF of 42 +/- 7 ml/ 100 g/min showed no change in T-2. Computer simulations accurately predicted these T-2 responses. The present study shows that the acute drop of CBFby 70% causes a negative BOLD that is readily detectable by T-2 MRI at 1.5T. Thus BOLD may serve as an index of misery perfusion thus revealing viable tissue with increased OER. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/11/20 alle ore 00:40:40