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Titolo:
Arterial spin labeling in combination with a look-locker sampling strategy: Inflow turbo-sampling EPI-FAIR (ITS-FAIR)
Autore:
Gunther, M; Bock, M; Schad, LR;
Indirizzi:
Deutsch Krebsforschungszentrum, Forschungssschwerpunkt Radiol Diagnost & Therapie, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg Germany D-69120 lberg, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 46, anno: 2001,
pagine: 974 - 984
SICI:
0740-3194(200111)46:5<974:ASLICW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; QUIPSS-II; PERFUSION; SEQUENCE; SLICE;
Keywords:
arterial spin labeling; perfusion; cerebral blood flow; Look-Locker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gunther, M Deutsch Krebsforschungszentrum, Forschungssschwerpunkt Radiol Diagnost & Therapie, Neuenheimer Feld 280,E0201, D-69120 Heidelberg, GermanyDeutsch Krebsforschungszentrum Neuenheimer Feld 280,E0201 Heidelberg Germany D-69120
Citazione:
M. Gunther et al., "Arterial spin labeling in combination with a look-locker sampling strategy: Inflow turbo-sampling EPI-FAIR (ITS-FAIR)", MAGN RES M, 46(5), 2001, pp. 974-984

Abstract

Arterial spin labeling (ASL) permits quantification of tissue perfusion without the use of MR contrast agents. With standard ASL techniques such as flow-sensitive alternating inversion recovery (FAIR) the signal from arterial blood is measured at a fixed inversion delay after magnetic labeling. As no image information is sampled during this delay, FAIR measurements are inefficient and time-consuming. In this work the FAIR preparation was combined with a Look-Locker acquisition to sample not one but a series of images after each labeling pulse. This new method allows monitoring of the temporaldynamics of blood inflow. To quantify perfusion, a theoretical model for the signal dynamics during the Look-Locker readout was developed and applied. Also, the imaging parameters of the new ITS-FAIR technique were optimizedusing an expression for the variance of the calculated perfusion. For the given scanner hardware the parameters were: temporal resolution 100 ms, 23 images, flip-angle 25.4 degrees. In a normal volunteer experiment with these parameters an average perfusion value of 48.2 +/- 12.1 ml/100 g/min was measured in the brain. With the ability to obtain ITS-FAIR time series with high temporal resolution arterial transit times in the range of -138 - 1054ms were measured, where nonphysical negative values were found in voxels containing large vessels. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:39:42