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Titolo:
Coronary magnetic resonance angiography: Experimental evaluation of the new rapid clearance blood pool contrast medium P792
Autore:
Taupitz, M; Schnorr, J; Wagner, S; Kivelitz, D; Rogalla, P; Claassen, G; Dewey, M; Robert, P; Corot, C; Hamm, B;
Indirizzi:
Humboldt Univ, Fak Med, Charite, Inst Radiol,Dept Radiol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 ept Radiol, D-10098 Berlin, Germany Guerbet, Roissy, France Guerbet Roissy FranceGuerbet, Roissy, France
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 46, anno: 2001,
pagine: 932 - 938
SICI:
0740-3194(200111)46:5<932:CMRAEE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; MR-ANGIOGRAPHY; GD-DTPA; AGENT; RABBITS; MOTION; INJECTION; ARTERIES;
Keywords:
contrast media; coronary arteries; animal studies; blood pool contrast media; magnetic resonance angiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Taupitz, M Humboldt Univ, Fak Med, Charite, Inst Radiol,Dept Radiol, Schumannstr 20-21, D-10098 Berlin, Germany Humboldt Univ Schumannstr 20-21 Berlin Germany D-10098 Germany
Citazione:
M. Taupitz et al., "Coronary magnetic resonance angiography: Experimental evaluation of the new rapid clearance blood pool contrast medium P792", MAGN RES M, 46(5), 2001, pp. 932-938

Abstract

The signal-enhancing characteristics of a new monodisperse monogadolinatedmacromolecular MR contrast medium (P792) were evaluated for magnetic resonance angiography (MRA) of the coronary arteries. A total of 15 cardiac examinations were performed in pigs at 1.5 T using a 3D gradient-echo sequence. Images were acquired during breath-hold before and up to 35 min after IV injection of Gd-DTPA (0.3 mmol Gd/kg), Gd-BOPTA (0.2 mmol Gd/kg), and P792 (13 mu mol Gd/kg). An increase in the signal-to-noise ratio (SNR) of 97% +/-17%,108% +/- 37%, and 109% +/- 31 % in coronary arteries and of 82% +/- 19%, 82% +/- 24%, and 28% +/- 18% in myocardium, respectively, was measured during the first postcontrast acquisition. The blood-to-myocardium signal-difference-to-noise ratio (SDNR) was significantly higher for P792 than for the other Gd compounds (P < .05) for up to 15 min after injection. Qualitative assessment showed that visualization of the coronary arteries and their branches was significantly better for P792 compared to the low-molecular Gdcompounds (P < .05). The blood pool contrast medium P792 is well suited for MRA of the coronary arteries. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:09:25