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Titolo:
Polyunsaturated fatty acids mapping by H-1 MR-chemical shift imaging
Autore:
Lunati, E; Farace, P; Nicolato, E; Righetti, C; Marzola, P; Sbarbati, A; Osculati, F;
Indirizzi:
Univ Verona, Fac Med, Sect Anat & Histol, Dept Morphol & Biomed Sci, I-37131 Verona, Italy Univ Verona Verona Italy I-37131 hol & Biomed Sci, I-37131 Verona, Italy
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 46, anno: 2001,
pagine: 879 - 883
SICI:
0740-3194(200111)46:5<879:PFAMBH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; MAGNETIC-RESONANCE; 4.7 TESLA; FISH-OIL; SPECTROSCOPY; RATS; LIPIDS;
Keywords:
fatty acids; brown adipose tissue; white adipose tissue; chemical shift imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sbarbati, A Univ Verona, Fac Med, Sect Anat & Histol, Dept Morphol & Biomed Sci, Strada Le Grazie 8, I-37131 Verona, Italy Univ Verona Strada Le Grazie 8 Verona Italy I-37131 na, Italy
Citazione:
E. Lunati et al., "Polyunsaturated fatty acids mapping by H-1 MR-chemical shift imaging", MAGN RES M, 46(5), 2001, pp. 879-883

Abstract

Parametric mapping of polyunsaturated fatty acids (PUFA) distribution in adipose tissues was obtained by H-1 chemical shift imaging (CSI). A matrix of spectra, acquired with a CSI sequence having two spatial and one spectroscopic dimension, was processed with ad hoc algorithms. The protocol was applied to phantoms containing different lipids in which the degree of polyunsaturation was determined by high-resolution nuclear magnetic resonance (NMR). High correlation (R-2 = 0.998) between degrees of polyunsaturation givenby our protocol and that measured by high-resolution NMR was found. The thoracic region of rats was also examined. Parametric maps of the polyunsaturation degree were obtained for the brown adipose tissue and the white axillary fat: the first deposit was found more polyunsaturated than the second. Finally, in vivo mapping of the inguinal region of the rat was produced that allowed us to individuate PUFA-rich areas in adipose tissue. This work demonstrates the feasibility of PUFA imaging in vivo. (C) 2001 Wiley-liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:55:34