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Titolo:
Effect of aqueous cigarette smoke extract on the chemiluminescence kinetics of polymorphonuclear leukocytes and on their glycolytic and phagocytic activity
Autore:
Zappacosta, B; Persichilli, S; Minucci, A; Di Stasio, E; Carlino, P; Pagliari, G; Giardina, B;
Indirizzi:
Univ Cattolica Sacro Cuore, Ist Chim & Chim Clin, Rome, Italy Univ Cattolica Sacro Cuore Rome Italy Ist Chim & Chim Clin, Rome, Italy Univ Cattolica Sacro Cuore, CNR, Ctr Chim Recettori, Rome, Italy Univ Cattolica Sacro Cuore Rome Italy , Ctr Chim Recettori, Rome, Italy Univ Cattolica Sacro Cuore, Cattedra Fisiopatol Resp, Rome, Italy Univ Cattolica Sacro Cuore Rome Italy edra Fisiopatol Resp, Rome, Italy
Titolo Testata:
LUMINESCENCE
fascicolo: 5, volume: 16, anno: 2001,
pagine: 315 - 319
SICI:
1522-7235(200109/10)16:5<315:EOACSE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICAL CHEMISTRY; PASSIVE SMOKING; HEART-DISEASE; LUMINESCENCE; TAR; EXPRESSION; FRACTIONS; EXPOSURE;
Keywords:
cigarette smoke; polymorphonuclear leukocytes; respiratory burst; chemiluminescence; membrane fluidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Zappacosta, B Policlin A Gemelli, Lab Chim Clin, Largo A Gemelli 8, I-00168 Rome, Italy Policlin A Gemelli Largo A Gemelli 8 Rome Italy I-00168 aly
Citazione:
B. Zappacosta et al., "Effect of aqueous cigarette smoke extract on the chemiluminescence kinetics of polymorphonuclear leukocytes and on their glycolytic and phagocytic activity", LUMINESCENC, 16(5), 2001, pp. 315-319

Abstract

Water-soluble extracts of cigarette smoke are easily formed in some body compartments, such as saliva or fluid lining alveolar spaces, and can act onboth cellular and extracellular compartments. In this paper we have analysed the effect of aqueous smoke extract on some metabolic and functional aspects of polymorphonuclear leukocytes. In particular, the following cellularaspects were studied: chemiluminescence, glycolysis, membrane fluidity andmicroscopic interaction with zymosan particles. While chemiluminescence and glycolytic activity are highly inhibited, no effect of smoke extract on membrane fluidity was observed. Moreover, the response of luminol-dependent chemiluminescence was significantly delayed, while that of lucigenin-dependent chemiluminescence was anticipated. Furthermore, the phagocytic ability of neutrophils pretreated with aqueous smoke extract was also significantlyhindered. All these results might indicate that the finely tuned activity of polymorphonuclear leukocytes is somehow hampered by the aqueous extract of cigarette smoke in a way which makes these cells less effective against bacteria and more noxious towards surrounding tissues. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:40:09