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Titolo:
Potent inhibitory effect of selective D-2 and D-3 agonists on dopamine-responsive dorsomedial arcuate neurons in brain slices of estrogen-primed rats
Autore:
Liang, SL; Pan, JT;
Indirizzi:
Natl Yang Ming Univ, Dept Physiol, Sch Life Sci, Taipei 11221, Taiwan NatlYang Ming Univ Taipei Taiwan 11221 h Life Sci, Taipei 11221, Taiwan
Titolo Testata:
LIFE SCIENCES
fascicolo: 22, volume: 69, anno: 2001,
pagine: 2653 - 2662
SICI:
0024-3205(20011019)69:22<2653:PIEOSD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-UNIT ACTIVITY; RECEPTOR MESSENGER-RNA; HYPOTHALAMIC ARCUATE; TISSUE SLICES; FEMALE RATS; D2; ACTIVATION; SECRETION; HORMONE;
Keywords:
dopamine autoreceptor; arcuate nucleus; single-unit recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Pan, JT Natl Yang Ming Univ, Dept Physiol, Sch Life Sci, Taipei 11221, Taiwan Natl Yang Ming Univ Taipei Taiwan 11221 ci, Taipei 11221, Taiwan
Citazione:
S.L. Liang e J.T. Pan, "Potent inhibitory effect of selective D-2 and D-3 agonists on dopamine-responsive dorsomedial arcuate neurons in brain slices of estrogen-primed rats", LIFE SCI, 69(22), 2001, pp. 2653-2662

Abstract

The possible involvement of dopamine D-2 and D-3 receptors in the action of dopamine (DA) on inhibiting dorsomedial arcuate nucleus (dmARN) neurons in brain slices was determined in this study. Fresh brain slices were prepared from ovariectomized, estrogen-primed Sprague-Dawley rats and used for extracellular single-unit recording. The dmARN neurons were first identified by their inhibitory responses to DA and then tested with PHNO and/or PD128907, selective D-1 and D-3 agonists, respectively. PD128907 in 5-50 nmole doses significantly inhibited the majority of DA-responsive dmARN neurons (86.3% of 44 units). Moreover, PHNO in 5-25 nmole doses inhibited all DA-responsive neurons tested (100% of 34 units). The inhibitory effects of PHNO andPD128907 were not only prominent; but also persisted in low Ca2+, high Mg2 medium, indicating that they were acting directly on the recorded neuron. Pretreatment of either raclopride or U99194A, D-2 and D-3 receptor antagonists respectively, reversed the effects of DA in a few trials. In contrast,SKF81297, a D-1 receptor agonist, induced variable responses in dmARN neurons. These results clearly indicate that DA may act through D-2 and/or D-3 receptors to exhibit an inhibitory effect on presumed TIDA neurons in dmARN. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:23:31