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Titolo:
Enhancement of fibrinolytics with a laser-induced liquid jet
Autore:
Hirano, T; Komatsu, M; Saeki, T; Uenohara, H; Takahashi, A; Takayama, K; Yoshimoto, T;
Indirizzi:
Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Inst Fluid Sci, Shock Wave Res Ctr, Sendai, Miyagi 9808577, Japan Tohoku Univ Sendai Miyagi Japan 9808577 tr, Sendai, Miyagi 9808577, Japan Natl Sendai Hosp, Dept Neurosurg, Sendai, Miyagi 9838520, Japan Natl Sendai Hosp Sendai Miyagi Japan 9838520 endai, Miyagi 9838520, Japan Tohoku Univ, Grad Sch Med, Dept Neuroendovasc Therapy, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 py, Sendai, Miyagi 9808574, Japan
Titolo Testata:
LASERS IN SURGERY AND MEDICINE
fascicolo: 4, volume: 29, anno: 2001,
pagine: 360 - 368
SICI:
0196-8092(2001)29:4<360:EOFWAL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; DURAL SINUS THROMBOSIS; CORONARY ANGIOPLASTY; RHEOLYTIC THROMBECTOMY; CEREBRAL EMBOLISM; OCCLUDED ARTERIES; TERRITORY STROKE; LOW-FREQUENCY; IN-VITRO; ULTRASOUND;
Keywords:
cerebral embolism; drug delivery; fibrinolytic agent; holmium-YAG laser; laser-induced bubble; liquid jet; shock wave;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, T Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, 1-1 Seiryou Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryou Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
T. Hirano et al., "Enhancement of fibrinolytics with a laser-induced liquid jet", LASER SURG, 29(4), 2001, pp. 360-368

Abstract

Background and Objective: There are several problems inherent in the treatment of cerebral embolisms, such as the narrow therapeutic time window and the severe side effects of fibrinolytic drugs. There is thus need of a new method of removing a cerebral thrombus more rapidly using smaller amounts of fibrinolytics. Study Design/Materials and Methods: The liquid-jet generator was made by insertion of an optical fiber (diameter: 0.6 mm) into a balloon catheter (6 Fr). A pulsed holmium (Ho) YAG laser (pulse duration time = 350 mus) was used as a laser source. The maximum penetration depth of a liquid jet generated with this device into a gelatin artificial thrombus was measured at various standoff distances (L; distance between the optical fiber end and the catheter exit). Based on the result, a stand-off distance of 13 mm was chosen to investigate the enhancement of urokinase (UK) efficacy by only a single operation of the liquid-jet device in artificial thrombi made of human blood. Results: Maximum penetration depth increased in proportion to L and reached a maximum value (9 mm) when L was around 13 mm. Fibrinolysis rates (%) after incubation with a small amount of UK for 10 and 30 minutes were predominantly raised by a single use of the laser-induced liquid jet (5.4 +/- 2.4 vs. 22.6 +/- 6.1 and 7.3 +/- 3.8 vs. 38.3 +/- 5.6, respectively (mean +/- SD, P < 0.001)). Conclusions: A laser-induced liquid jet effectively promoted fibrinolysis in vitro with use of only a small amount of fibrinolytics. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:21:54