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Titolo:
Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma
Autore:
To, Y; Dohi, M; Tanaka, R; Sato, A; Nakagome, K; Yamamoto, K;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 heumatol, Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
LABORATORY INVESTIGATION
fascicolo: 10, volume: 81, anno: 2001,
pagine: 1385 - 1396
SICI:
0023-6837(200110)81:10<1385:EI4RCI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR GATA-3; ALLERGEN-SPECIFIC TH1; IL-5 MESSENGER-RNA; T-CELLS; EOSINOPHILIC INFLAMMATION; SUPLATAST TOSILATE; MURINE MODEL; LUNG DAMAGE; BRONCHIAL RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Dohi, M Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 , Tokyo 1138655, Japan
Citazione:
Y. To et al., "Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma", LAB INV, 81(10), 2001, pp. 1385-1396

Abstract

in experimental models of bronchial asthma with mice, airway inflammation and increase in airway hyperreactivity (AHR) are induced by a combination of systemic sensitization and airway challenge with allergens. In this report, we present another possibility: that systemic antigen-specific sensitization alone can induce AHR before the development of inflammation in the airway. Male BALB/c mice were sensitized with ovalbumin (OVA) by a combinationof intraperitoneal injection and aerosol inhalation, and various parameters for airway inflammation and hyperreactivity were sequentially analyzed. Bronchial response measured by a noninvasive method (enhanced pause) and theeosinophil count and interleukin (IL)-5 concentration in bronchoalveolar lavage fluid (BALF) gradually increased following the sensitization, and significant increase was achieved after repeated OVA aerosol inhalation along with development of histologic changes of the airway. In contrast, AHR was already significantly increased by systemic sensitization alone, although airway inflammation hardly developed at that time point. BALF IL-4 concentration and the expression of IL-4 mRNA in the lung reached maximal values after the systemic sensitization, then subsequently decreased. Treatment of mice with anti-IL-4 neutralizing antibody during systemic sensitization significantly suppressed this early increase in AHR. In addition, IL-4 gene-targeted mice did not reveal this early increase in AHR by systemic sensitization. These results suggest that an immune response in the lung in an early stage of sensitization can induce airway hyperreactivity before development of an eosinophilic airway inflammation in BALB/c mice and that IL-4 plays an essential role in this process. If this early increase in AHR does occur in sensitized human infants, it could be another therapeutic target for early prevention of the future onset of asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 09:16:28