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Titolo:
Colocalization of ANCA-antigens and fibrinoid necrosis in ANCA-associated vasculitis
Autore:
Bajema, IM; Hagen, EC; de Heer, E; van der Woude, J; Bruijn, JA;
Indirizzi:
Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Eemland Hosp Lichtenberg, Amersfoort, Netherlands Eemland Hosp Lichtenberg Amersfoort Netherlands Amersfoort, Netherlands Univ Heidelberg, Med Fac Mannheim, Med Dept 5, Heidelberg, Germany Univ Heidelberg Heidelberg Germany eim, Med Dept 5, Heidelberg, Germany
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 60, anno: 2001,
pagine: 2025 - 2030
SICI:
0085-2538(200111)60:5<2025:COAAFN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC SYSTEMIC VASCULITIS; WEGENERS GRANULOMATOSIS; NEUTROPHILS; AUTOANTIBODIES; PROTEINASE-3; ANTIBODIES; INVITRO; DAMAGE;
Keywords:
Wegener's granulomatosus; small vessel vasculitides; proteinase-3; myeloperoxidase; microscopic polyangiitis; polymorphonuclear cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bajema, IM Leiden Univ, Med Ctr, Dept Pathol, L1-Q,POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ L1-Q,POB 9600 Leiden Netherlands NL-2300 RC rlands
Citazione:
I.M. Bajema et al., "Colocalization of ANCA-antigens and fibrinoid necrosis in ANCA-associated vasculitis", KIDNEY INT, 60(5), 2001, pp. 2025-2030

Abstract

A variety of antineutrophil cytoplasmic auto-antibodies (ANCAs) are known to be associated with small vessel vasculitides such as Wegener's granulomatosis and microscopic polyangiitis. To visualize colocalization patterns ofthe fibrinoid necrotic lesions and ANCA-antigens more accurately, we have developed a double staining technique in which an immunohistochemical staining is followed by a histological staining. Instead of using sequential biopsy slides of histologically and immunohistochemically stained sections, which may lead to an underestimation of the number and size of the lesions, our technique permits the visualization of the colocalized patterns of fibrinoid necrosis with an ANCA-antigen in a single slide. The double staining procedure is presented in this Technical Note.

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Documento generato il 04/12/20 alle ore 09:48:03