Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of COX-2 counteracts the effects of diuretics in rats
Autore:
Kammerl, MC; Nusing, RM; Richthammer, W; Kramer, BK; Kurtz, A;
Indirizzi:
Univ Regensburg, Inst Physiol 1, D-93053 Regensburg, Germany Univ Regensburg Regensburg Germany D-93053 , D-93053 Regensburg, Germany Univ Marburg, Dept Pediat, Marburg, Germany Univ Marburg Marburg Germany niv Marburg, Dept Pediat, Marburg, Germany Univ Klin Regensburg, Klin & Poliklin Innere Med 2, Regensburg, Germany Univ Klin Regensburg Regensburg Germany nere Med 2, Regensburg, Germany
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 60, anno: 2001,
pagine: 1684 - 1691
SICI:
0085-2538(200111)60:5<1684:IOCCTE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOOXYGENASE-2 EXPRESSION; MACULA DENSA; RENIN; CHLORIDE; HEMODYNAMICS; TRANSPORT; RELEASE; URINE; RNA;
Keywords:
salt and water wasting; Bartter disease; Gitelman disease; loop diuretics; furosemide; hydrochlorothiazide; renin system; prostaglandins; saluresis; urinary excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kammerl, MC Univ Regensburg, Inst Physiol 1, Univ Str 31, D-93053 Regensburg, Germany Univ Regensburg Univ Str 31 Regensburg Germany D-93053 ermany
Citazione:
M.C. Kammerl et al., "Inhibition of COX-2 counteracts the effects of diuretics in rats", KIDNEY INT, 60(5), 2001, pp. 1684-1691

Abstract

Background. It is well established that the diuretic- and renin-stimulatedeffects of loop diuretics can be attenuated by nonselective cyclooxygenaseinhibitors. Since it is yet unclear which of the isoforms of cyclooxygenases, COX-1 and COX-2, is relevant in this context, our study aimed to determine the effects of selective COX-2 inhibition on the renal effects of the loop diuretic furosemide, as well as the diuretic hydrochlorothiazide, whichacts on the distal tubule. Method. Male Sprague-Dawley rats were treated with furosemide (12 mg/day subcutaneously by osmotic pump) or hydrochlorothiazide (30 mg/kg body weight/day orally by gavage). In addition, parallel groups received rofecoxib (1 to 10 mg/kg body weight/day) for selective inhibition of COX-2. Controls were treated with vehicle. Results. Induction of COX-2 mRNA expression due to furosemide was paralleled by increased renal excretion of prostanoids. Also, hydrochlorothiazide led to a rise in prostanoid excretion. Rofecoxib blunted the diuretic-induced increase in prostanoid excretion, thus confirming an effective blockade of COX-2. Moreover, the COX-2 inhibitor rofecoxib dose-dependently attenuated diuresis and saluresis, as well as the stimulation of the renin system induced by furosemide. Furthermore, rofecoxib completely reversed diuresis and saluresis and prevented the increase of plasma renin activity induced by hydrochlorothiazide. Conclusions. These findings suggest that COX-2-derived prostanoids are of major relevance in modulating the renal effects of diuretics. COX-2 inhibitors might be valuable drugs to treat salt and water wasting during Bartter and Gitelman diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:23:54