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Titolo:
Role of the aryl hydrocarbon receptor in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed male mice
Autore:
Lin, TM; Ko, K; Moore, RW; Buchanan, DL; Cooke, PS; Peterson, RE;
Indirizzi:
Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 sin, Sch Pharm, Madison, WI 53705 USA Univ Wisconsin, Endocrinol Reprod Physiol Program, Sch Pharm, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 ram, Sch Pharm, Madison, WI 53705 USA Univ Wisconsin, Ctr Environm Toxicol, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 vironm Toxicol, Madison, WI 53705 USA Univ Illinois, Dept Vet Biosci, Urbana, IL 61801 USA Univ Illinois UrbanaIL USA 61801 , Dept Vet Biosci, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 4, volume: 64, anno: 2001,
pagine: 327 - 342
SICI:
1528-7394(20011026)64:4<327:ROTAHR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT MICE; AH-RECEPTOR; HEMATOPOIETIC-CELLS; BONE-MARROW; MOUSE; TCDD; ACTIVATION; LACKING; INVOLVEMENT; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Peterson, RE Univ Wisconsin, Sch Pharm, 777 Highland Ave, Madison, WI 53705 USA Univ Wisconsin 777 Highland Ave Madison WI USA 53705 3705 USA
Citazione:
T.M. Lin et al., "Role of the aryl hydrocarbon receptor in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed male mice", J TOX E H A, 64(4), 2001, pp. 327-342

Abstract

Experiments were conducted to determine the role of the aryl hydrocarbon receptor (AhR) in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)exposed C57B1/6 male mice. Male and female mice heterozygousfor the AhR (Ahr(+/-)) were mated, and pregnant females were dosed orally on gestation day 13 with corn oil vehicle or TCDD (5 mug/kg). Pups were necropsied on postnatal day (PND) 21, 35, and 90. Comparison of vehicle-exposed wild-type (Ahr(+/+)) pups with vehicle-exposed AhR knockout (AhRKO; Ahr(-/-)) pups confirmed and extended previous reports that development of the liver, heart, spleen, thymus, and kidney is affected by absence of the AhR. Lung, submandibular gland, testis, and epididymis weights were also affected, indicating that the AhR plays a role in normal development of these organs as well. The presence or absence of the AhR had no effect on the incidence of hydronephrosis, daily sperm production, or cauda epididymal sperm numbers in vehicle-exposed mice. TCDD caused numerous effects in wild-type mice that were absent in AhRKO mice; specifically, hydronephrosis, increases in relative liver and heart weight, decreases in absolute heart and lung weight, and decreases in absolute and relative thymus, submandibular gland, epididymis, and testis weight. In several cases, TCDD produced one effect in wild-type mice (reductions in body weight and absolute thymus, submandibular gland, and epididymis weight on PND 21; and reductions in absolute and relative submandibular gland and absolute testis weight on PND 35) but causedthe opposite effect in AhRKO mice. In yet other cases (reduced relative spleen weight on PND 21 and reductions in absolute and relative thymus weighton PND 35), TCDD produced similar effects in wildtype and AhRKO mice. There were also cases in which TCDD significantly affected AhRKO mice without significantly altering the same endpoint in wild-type mice; absolute liver, lung, and kidney weight were increased and relative submandibular gland weight was decreased on PND 21; relative heart weight was reduced and absolutelung weight increased on PND 35; and relative liver weight was decreased on PND 90. Although many effects of TCDD required the presence of the AhR, these results provide evidence either for multiple forms of the AhR in mice (one or more of which are still present in AhRKO mice), or for AhR-independent effects of low-level TCDD exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:16:03