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Titolo:
Iron tetrakis (N-methyl-4 '-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-kappa B activation of raw 264.7 macrophages
Autore:
Kang, JHL; Lee, HS; Pack, IS; Leonard, S; Castranova, V;
Indirizzi:
Ewha Womans Univ, Dept Physiol,Ewha Med Res Ctr, Coll Med,Div Cell Biol, Yangcheon Ku, Seoul 158056, South Korea Ewha Womans Univ Seoul South Korea158056 Ku, Seoul 158056, South Korea
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 4, volume: 64, anno: 2001,
pagine: 291 - 310
SICI:
1528-7394(20011026)64:4<291:IT('P(>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXYNITRITE DECOMPOSITION CATALYSTS; TRANSCRIPTION FACTOR; NITRIC-OXIDE; TYROSINE PHOSPHORYLATION; LIPID-PEROXIDATION; TNF-ALPHA; IN-VIVO; SILICA; DEGRADATION; SIGNAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kang, JHL Ewha Womans Univ, Dept Physiol,Ewha Med Res Ctr, Coll Med,Div Cell Biol, Yangcheon Ku, 911-1 Mok-6-Dong, Seoul 158056, South Korea Ewha Womans Univ 911-1 Mok-6-Dong Seoul South Korea 158056 orea
Citazione:
J.H.L. Kang et al., "Iron tetrakis (N-methyl-4 '-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-kappa B activation of raw 264.7 macrophages", J TOX E H A, 64(4), 2001, pp. 291-310

Abstract

Metalloporphyrins have been shown to be protective in oxidative stress models. However, the molecular basis for the antioxidative and antiinflammatory activities of iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) is not known. The objective of this study was to determine whether FeTMPyP exhibited the ability to (1) scavenge reactive oxygen species (ROS), (2) inhibit the activation of nuclear factor kappa 8 (NF-kappaB), or (3) block the production of interleukin 1 (IL-1) in RAW 264.7 cultured macrophages. Theresults indicate that FeTMPyP is a potent scavenger of hydroxyl radicals and superoxide anion radicals, and an effective inhibitor of stimulant-induced NF-kappaB activation and IL-1 production by RAW 264.7 cells. Therefore, FeTMPyP may be a useful tool to investigate the molecular mechanisms involved in stimulant-induced signal pathways, and may possess therapeutic utility in diseases associated with overproduction of ROS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 20:23:56