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Titolo:
Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy
Autore:
Womer, KL; Stone, JR; Murphy, B; Chandraker, A; Sayegh, MH;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Renal Div,Lab Immunogenet & Transplantat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 net & Transplantat, Boston, MA 02115 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Mt Sinai Sch Med, Div Renal, New York, NY USA Mt Sinai Sch Med New York NY USA ai Sch Med, Div Renal, New York, NY USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2500 - 2506
SICI:
1046-6673(200111)12:11<2500:IAODCI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; INDIRECT RECOGNITION; ALLOGRAFT-REJECTION; GRAFT-REJECTION; MHC PEPTIDES; RECIPIENTS; ALLOPEPTIDES; MECHANISMS; ANTIGEN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sayegh, MH Harvard Univ, Brigham & Womens Hosp, Sch Med, Renal Div,Lab Immunogenet & Transplantat, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 on, MA 02115 USA
Citazione:
K.L. Womer et al., "Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy", J AM S NEPH, 12(11), 2001, pp. 2500-2506

Abstract

Recent clinical and experimental evidence suggests that indirect allorecognition may promote the development of chronic rejection, but definitive experimental studies are lacking. To study the contribution of indirect allorecognition to chronic rejection, naive Lewis (RT1(1)) rats were immunized with synthetic Wistar Furth (WF) class II-RT1(u).D (HLA-DR-like) or -RT1(u).B(HLA-DQ-like) or class I-RT1(u).A (HLA-Alike) peptides emulsified in complete Freund's adjuvant 7 d before transplantation (n = 5 to 7/group). Experimental and control animals then acted as recipients of fully mismatched WF vascularized cardiac allografts. Recipients received immunosuppression in the form of cyclosporine at a tapering dose that allows for long-term allograft survival. Animals were sacrificed at either 3 or 6 mo, with allograft arterial luminal occlusion scored on elastin stains by a blinded observer. At 3 mo, mean vessel scores were significantly higher in the RT1(u).A- immunized versus class II-immunized and control groups (P < 0.05). By 6 mo, there was progression of chronic allograft vasculopathy and a significantly higher mean vessel score in the RT1(u).A- and RT1(u).D-immunized versus RT1(u). B and control groups (P < 0.05). In vitro studies show evidence of shifting MHC allopeptide immunogenicity. It was concluded that T cells primed by specific donor class I and II MHC allopeptides promote the development of chronic vascularized allograft rejection. These novel observations provide definitive evidence of a link between indirect allorecognition and the development and progression of chronic rejection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:13:05