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Titolo:
CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disorders
Autore:
Sharma, RP; Martis, B; Rosen, C; Jonalagadda, J; Nemeroff, CB; Bissette, G;
Indirizzi:
Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Dept Psychiat, Chicago, IL 60612 USA Univ Mississippi, Sch Med, Dept Psychiat, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 ept Psychiat, Jackson, MS 39216 USA Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA Emory Univ Atlanta GA USA ed, Dept Psychiat & Behav Sci, Atlanta, GA USA
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 5, volume: 35, anno: 2001,
pagine: 287 - 291
SICI:
0022-3956(200109/10)35:5<287:CTHCDI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; DEPRESSED-PATIENTS; TSH RESPONSE; TRH; VASOPRESSIN;
Keywords:
cerebrospinal fluid; thyrotropin-releasing hormone; schizoaffective disorder; schizophrenia; mood disorders; antipsychotic treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, RP Univ Illinois, Inst Psychiat, Dept Psychiat, 1601 W Taylor St, Chicago, IL60612 USA Univ Illinois 1601 W Taylor St Chicago IL USA 60612 IL60612 USA
Citazione:
R.P. Sharma et al., "CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disorders", J PSYCH RES, 35(5), 2001, pp. 287-291

Abstract

Objective: To determine if there were differences in CSF-TRH concentrations among several acute major psychiatric disorders and to investigate the effects of antipsychotic treatment on CSF-TRH levels. Method: CSF-TRH concentrations were measured in 62 psychiatric inpatients during an acute phase ofillness after a drug-free period. CSF-TRH measurements were repeated in 14of these patients after 4 weeks of antipsychotic treatment. Results: Post-hoc tests (Tukey HSD) revealed significant differences among patients with schizoaffective disorder and both schizophrenia (P < 0.03) and major depression (P < 0.01). There were no significant differences between pre and posttreatment levels of CSF-TRH in the 14 patients treated with conventional agents for 4 weeks (1.54 pg/ml vs. 1.47 pg/ml). However, patients with a reduction in CSF-TRH concentration had a significantly beater symptom response measured by the Brief Psychiatric Rating Scale (BPRS) positive factor (61% in six subjects) vs. those who had an increase in posttreatment CSF-TRH (29% in eight subjects: t = 2.2: d.f. = 12: P < 0.04). Conclusions: These results provide further evidence for a neuromodulatory role for TRH and suggesta re-examination of its behavioral effects and interactions with brain neurotransmitter systems relevant to major psychotic and mood disorders. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 23/01/20 alle ore 19:18:18