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Titolo:
Reduced olfactory performance in patients with major depression
Autore:
Pause, BM; Miranda, A; Goder, R; Aldenhoff, JB; Ferstl, R;
Indirizzi:
Univ Kiel, Dept Psychol, D-24098 Kiel, Germany Univ Kiel Kiel Germany D-24098 Kiel, Dept Psychol, D-24098 Kiel, Germany Univ Kiel, Dept Psychiat & Psychotherapy, D-24098 Kiel, Germany Univ KielKiel Germany D-24098 at & Psychotherapy, D-24098 Kiel, Germany
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 5, volume: 35, anno: 2001,
pagine: 271 - 277
SICI:
0022-3956(200109/10)35:5<271:ROPIPW>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
STARTLE REFLEX; ALZHEIMERS DEMENTIA; UNPLEASANT ODORS; BLOOD-FLOW; HUMANS; PLEASANT; STIMULATION; DYSFUNCTION; RESPONSES; DISORDERS;
Keywords:
major depression; olfactory sensitivity; odor intensity; odor valence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Pause, BM Univ Kiel, Dept Psychol, Olshaussenstr 62, D-24098 Kiel, GermanyUniv Kiel Olshaussenstr 62 Kiel Germany D-24098 8 Kiel, Germany
Citazione:
B.M. Pause et al., "Reduced olfactory performance in patients with major depression", J PSYCH RES, 35(5), 2001, pp. 271-277

Abstract

The aim of the present study is to investigate olfactory sensitivity and odor evaluations in a homogenous sample of unipolar depressive patients using pure olfactory odors. Twenty-four in-patients with major depressive disorder (MDD) were investigated during their acute depressive phase. Eighteen of them participated a second time after Successful treatment. A group of healthy subjects, matched by age. sex, and smoking behavior. served as a control. Olfactory sensitivity, as measured by threshold tests, was strongly reduced in patients with severe depression. Additional correlative analyses revealed that the lowered sensitivity could partly be predicted by high depression scores. After successful medical treatment. these sensitivity differences were reduced and did not reach the significance level. The subjectiveodor evaluations (valence and intensity ratings) were not markedly changedin general. The results reveal that olfactory performance in MDD patients is reduced at an early perceptional level of stimulus processing. It is discussed whether this effect can be attributed to the close functional connection between the main olfactory bulb and the amygdala. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 22/01/20 alle ore 13:29:08