Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gradient of sodium current across the left ventricular wall of adult rat hearts
Autore:
Ashamalla, SM; Navarro, D; Ward, CA;
Indirizzi:
Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 2, volume: 536, anno: 2001,
pagine: 439 - 443
SICI:
0022-3751(20011015)536:2<439:GOSCAT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-QT SYNDROME; TRANSIENT OUTWARD CURRENT; PROTEIN-KINASE-C; CARDIAC MEMORY; CHANNEL; MYOCYTES; REPOLARIZATION; DISPERSION; MECHANISMS; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ward, CA Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 gston, ON K7L 3N6, Canada
Citazione:
S.M. Ashamalla et al., "Gradient of sodium current across the left ventricular wall of adult rat hearts", J PHYSL LON, 536(2), 2001, pp. 439-443

Abstract

1. Gradients of ion channels across the left ventricular (LV) wall have been well characterized and it has been shown that disruption of such gradients leads to altered rates of repolarization across the wall, which is associated with the generation of arrhythmias.2. We have hypothesized that a transmural gradient of I-Na is present and have directly measured this current in adult rat myocytes isolated from both the epicardial and endocardial layers of the left ventricle. Currents were also recorded in right ventricular (RV) myocytes for comparison.3. Peak inward I-Na. currents, at -30 mV, were -49.7 +/- 2.5 pA pF(-1) (n = 22), -32.9 +/- 3.2 pA pF(-1) (n = 16) and -49.7 +/- 3.7 pA pF(-1) (n = 24) for RV, LV epicardial and LV endocardial myocytes, respectively. No differences in the voltage dependence of inactivation, the voltage dependence ofsteady-state inactivation, or reactivation were reported.4. Our results demonstrate that a gradient of sodium current density is present across the LV wall of adult rat hearts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:14:23