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Titolo:
Endogenous interaction of glutamate and dopamine in the basal ganglia of the awake rat during aging
Autore:
Mora, F; del Arco, A; Segovia, G;
Indirizzi:
Univ Complutense, Fac Med, Dept Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 ept Physiol, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 2, volume: 57, anno: 2001,
pagine: 97 - 104
SICI:
1138-7548(200106)57:2<97:EIOGAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RAT; METHYL-D-ASPARTATE; NUCLEUS-ACCUMBENS; STRIATAL DOPAMINE; EXTRACELLULAR CONCENTRATIONS; INVIVO MICRODIALYSIS; FISCHER-344 RAT; EVOKED RELEASE; NITRIC-OXIDE; RECEPTORS;
Keywords:
aging; glutamate; dopamine; GABA; striatum; nucleus accumbens; microdialysis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mora, F Univ Complutense, Fac Med, Dept Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 iol, E-28040 Madrid, Spain
Citazione:
F. Mora et al., "Endogenous interaction of glutamate and dopamine in the basal ganglia of the awake rat during aging", J PHYSIOL B, 57(2), 2001, pp. 97-104

Abstract

The interaction of glutamate and dopamine in the basal ganglia of fully conscious rat during the normal process of aging is reviewed. Using a novel approach, that of blocking the reuptake of glutamate, the effects of increasing concentrations of endogenous glutamate on the extracellular concentrations of dopamine in striatum and nucleus accumbens in the young rat were investigated. It was found that increasing concentrations of glutamate correlated significantly with increasing concentrations of dopamine in striatum and nucleus accumbens. Moreover the increase of dopamine in both structures was significantly reduced after blockade of NMDA and AMPA/kainate glutamate receptors, suggesting that the increase of dopamine was mediated by glutamate. The interaction glutamate/dopamine expressed by its ratio showed a significant age-related decrease in nucleus accumbens but not in striatum, so that to a given amount of glutamate less increase of dopamine is produced. It is suggested that the interaction glutamate-dopamine represents a balanced input to the GABA neuron in the basal ganglia and that during aging this balance is disrupted. In addition, we also speculate on the significance ofthis glutamate-dopamine disruption in relation to the changes in motor behavior found with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:05:22