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Titolo:
Renal effects of dopamine and ANP in high volume expanded rats
Autore:
Balaszczuk, AM; Fellet, AL;
Indirizzi:
Univ Buenos Aires, Fac Farm & Bioquim, Catedra Fisiol, Fdn Barcelo,IQUIMEFA,PROSIVAD,CONICET, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1113 Aires, DF, Argentina
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 2, volume: 57, anno: 2001,
pagine: 81 - 87
SICI:
1138-7548(200106)57:2<81:REODAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-FACTOR; SPONTANEOUSLY HYPERTENSIVE RATS; K+-ATPASE ACTIVITY; INTRARENAL DOPAMINE; SODIUM-METABOLISM; PROXIMAL TUBULE; RECEPTORS; PEPTIDE; HYPERVOLEMIA; EXPANSION;
Keywords:
kidney; dopamine; atrial natriuretic peptide; volume expansion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Balaszczuk, AM Univ Buenos Aires, Fac Farm & Bioquim, Catedra Fisiol, Fdn Barcelo,IQUIMEFA,PROSIVAD,CONICET, RA-1113 Buenos Aires, DF, Argentina UnivBuenos Aires Buenos Aires DF Argentina RA-1113 entina
Citazione:
A.M. Balaszczuk e A.L. Fellet, "Renal effects of dopamine and ANP in high volume expanded rats", J PHYSIOL B, 57(2), 2001, pp. 81-87

Abstract

Both dopamine (DA) and atrial natriuretic peptide (ANP) have been postulated to exert similar effects on the kidney, participating in the regulation of body fluid and sodium homeostasis. In the present study, experiments were performed in anesthetized and isotonic sodium chloride volume expanded rats. After acute volume expansion at 15 % of body weight during 30 min, glomerular filtration rate, urine output, sodium excretion, fractional sodium excretion, proximal and distal sodium excretion and blood pressure were measured. In additional groups we administered ANP or haloperidol or the combination of both to volume expanded animals. Blockade of DA receptors with haloperidol, attenuated diuretic and natriuretic responses to volume load. Proximal sodium excretion was not modified by haloperidol in all experimental groups of rats. Reduction in distal tubular excretion was induced by haloperidol in saline infusion expanded rat but not in ANP treated expanded animals. In conclusion, when exaggerated volume expansion is provoked, both DA and ANP exert renal tubular events, but ANP have a major central role in theregulation of renal sodium handling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:07:06