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Titolo:
Dietary saturated fatty acids reverse inflammatory and fibrotic changes inrat liver despite continued ethanol administration
Autore:
Nanji, AA; Jokelainen, K; Tipoe, GL; Rahemtulla, A; Dannenberg, AJ;
Indirizzi:
Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Ctr Study Liver Dis, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Helsinki, Cent Hosp, Alcohol Dis Res Unit, Helsinki, Finland Univ Helsinki Helsinki Finland Alcohol Dis Res Unit, Helsinki, Finland Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Cornell Univ, Weill Med Coll, Dept Med, New York, NY USA Cornell Univ NewYork NY USA Weill Med Coll, Dept Med, New York, NY USA Strong Canc Prevent Ctr, Anne Fisher Nutr Ctr, New York, NY USA Strong Canc Prevent Ctr New York NY USA isher Nutr Ctr, New York, NY USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 2, volume: 299, anno: 2001,
pagine: 638 - 644
SICI:
0022-3565(200111)299:2<638:DSFARI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-KAPPA-B; LIPID-PEROXIDATION; ALCOHOLIC HEPATITIS; GENE-EXPRESSION; FISH-OIL; DISEASE; INJURY; SEVERITY; CYCLOOXYGENASE-2; PATHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nanji, AA Queen Mary Hosp, Clin Biochem Unit, LG 136,Block K,102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp LG 136,Block K,102 Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
A.A. Nanji et al., "Dietary saturated fatty acids reverse inflammatory and fibrotic changes inrat liver despite continued ethanol administration", J PHARM EXP, 299(2), 2001, pp. 638-644

Abstract

We investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six rats/group) of male Wistar rats were studied. Rats in groups 1 and 2 were fed a fish oil-ethanol diet for 8 and 6 weeks, respectively. Rats in groups 3 and 4 were fed fish oil and ethanol for 6 weeks before being switched to isocaloric diets containing ethanol with palm oil (group 3) or medium-chain triglycerides (MCTs, group 4) for 2 weeks. Rats in group 5 were fed fish oil and dextrose for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, nuclear factor-kappaB (NF-kappaB) activation, and mRNAs for cyclooxygenase-2 (Cox-2) and tumor necrosis factor-alpha (TNF-alpha). Endotoxin in plasma was determined. The most severe inflammation and fibrosis were detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, activation of NF-kappaB, and mRNAs for Cox-2 and TNF-alpha. After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-kappaB activation, and reduced expression of TNF-alpha and Cox-2. A diet enriched in saturated fatty acids effectively reverses alcohol-induced necrosis, inflammation, and fibrosis despite continued alcohol consumption. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-kappaB and reduced levels of TNF-alpha and Cox-2.

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Documento generato il 09/07/20 alle ore 22:28:40