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Titolo:
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylaseactivity in macrophages
Autore:
Kapoor, P; Rai, VS; Saxena, S; Balaraman, S; Madhubala, R;
Indirizzi:
Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India Jawaharlal Nehru Univ New Delhi India 110067 ci, New Delhi 110067, India
Titolo Testata:
JOURNAL OF PARASITOLOGY
fascicolo: 5, volume: 87, anno: 2001,
pagine: 1071 - 1076
SICI:
0022-3395(200110)87:5<1071:EOLDLO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ACCESSORY CELL-INTERACTIONS; SIGNAL TRANSDUCTION; MESSENGER-RNA; PERITONEAL-MACROPHAGES; INFECTED MACROPHAGES; MURINE LEISHMANIASIS; OKADAIC ACID; EXPRESSION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kapoor, P Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India Jawaharlal Nehru Univ New Delhi India 110067 lhi 110067, India
Citazione:
P. Kapoor et al., "Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylaseactivity in macrophages", J PARASITOL, 87(5), 2001, pp. 1071-1076

Abstract

Lipophosphoglycan (LPG), a major surface molecule from Leishmania donovani, stimulated ornithine decarboxylase (ODC) activity in macrophages in a dose- and time-dependent manner. LPG stimulated the rapid increase in ODC activity within 30 min after exposure, suggesting that the interaction of LPG with its receptor stimulated a specific signal transduction pathway. However, LPG-induced ODC activity was a transient event because 3 hr after exposure to LPG, no stimulation of ODC activity was detectable. ODC activity appeared to be coupled to the activation of protein kinase C (PKC) in macrophages, as activators of PKC caused a rapid increase in the ODC activity. Macrophages pretreated with LPG for I hr became unresponsive to subsequent stimulation by the PKC activators 1-oleoyl-2-acetyl-glycerol and the calcium ionophore A23187. In contrast, the ability of macrophages to express ODC activity in response to the cyclic AMP analogue dibutyryl cyclic AMP was not impaired by LPG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:32:42